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Diss Factsheets
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EC number: 246-874-9 | CAS number: 25340-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
For DEB mixed isomers, limited toxicokinetic data are available only for the 1,2-DEB isomer. In mammals, 1,2-DEB is absorbed and metabolized rapidly after oral or i.v. exposure; the majority is excreted via urine or feces, after extensive enterohepatic recirculation. Systemic availability after oral is very similar to i.v. dosing indicating that 1,2 -DEB is well absorbed through the guts.
Oxidation of 1,2-DEB to the gamma-diketone 1,2-diacetylbenzene and its subsequent urinary elimination have been demonstrated. A metabolite of 1,2 -DEB is considered to be responsible for the blue coloring of tissues and fluids in rats exposed to mixed DEB. The same blueish coloring is observed with 1,2 -Diactetylbenzene indicating a common metabolite of both. This blue coloring is not considered to be an 'adverse effect'.
Although there exists data only on 1,2 -DEB, it is considered likely that the other isomers (1,3 and 1,4 -DEB) will also be well absorbed following oral administration with subsequent excretion via the bile and urine.
From the available repeated dose studies on the mixed isomers of DEB, all three isomers of DEB appear to be absorbed following inhalation exposure. Due to the high degree of bioavailability following oral exposure it is considered that inhalation and oral exposure would lead to similar levels of systemic exposure for the purposes of route to route extrapolation (where necessary).
There are no dermal toxicokinetic data available, however due to the volatility of DEB mixed isomers it is unlikely that dermal exposure will lead to significant systemic exposure given the tendency of this material to evaporate. A similar conclusion was reached for similar branched aromatic compounds such as ethylbenzene and styrene. The dermal penetration of ethylbenzene is considered to be approx 3 -4% of the applied dose, with the remainder evaporating. However the vapour pressure of DEB is approximately one third of that of ethyl benzene, and therefore DEB will persist on the skin to a greater extent compared to Ethylbenzene. Taking this into consideration it is estimated that dermal penetration of mixed DEB could be as high as 10% under unnocluded conditions. This is consistent with the observations of acute dermal and oral toxicity studies with the DEB mixed isomers where toxicity via dermal exposure was less than via oral.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.