Registration Dossier
Registration Dossier
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EC number: 204-671-2 | CAS number: 124-02-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Diallylamine [124-02-7]: Review of Toxicological Literature
- Author:
- US National Toxicology Program
- Year:
- 1 997
- Bibliographic source:
- US National Toxicology Program
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.1 mL diallylamine was applied into one eye of rabbit. Observations were made 1, 2, 3 and 7 days after dosing.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diallylamine
- EC Number:
- 204-671-2
- EC Name:
- Diallylamine
- Cas Number:
- 124-02-7
- Molecular formula:
- C6H11N
- IUPAC Name:
- diallylamine
Constituent 1
- Specific details on test material used for the study:
- Purity not provided.
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Age and sex of rabbits not specified.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- Single dose.
- Observation period (in vivo):
- Observations were made 1, 2, 3 and 7 days after dosing.
- Number of animals or in vitro replicates:
- 6 rabbits.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: corneal damage
- Time point:
- other: 1, 2, 3 and 7 days
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: severe corneal damage
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritation parameter:
- other: chemosis
- Time point:
- other: 1, 2, 3 and 7 days
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: chemosis (edema of the bulbar conjunctiva)
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritation parameter:
- other: conjunctiva
- Remarks:
- (discharge)
- Time point:
- other: 1, 2, 3 and 7 days
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: discharge of the conjunctivae
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritation parameter:
- other: erythema
- Time point:
- other: 1, 2, 3 and 7 days
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: severe erythema
- Remarks:
- This was a published study not performed according to a guideline. Without the current guideline format, it has not been possible to fully complete this table.
- Irritant / corrosive response data:
- Severe corneal damage, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge of the conjunctivae were observed one, two, three and seven days after application.
It was not specified at what time damage occurred, but there were no signs of remission at seven days after treatment.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Severe corneal damage was observed. In the conjunctivae, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge were observed. There were no signs of remission 7 days after treatment.
- Executive summary:
In six New Zealand White rabbits, severe erythema, chemosis (edema of the bulbar conjunctiva), and discharge of the conjunctivae were observed one, two, three and seven days after application of 0,1 mL diallylamine into one eye.
It was not specified at what time damage occurred, but there were no signs of remission at seven days after treatment.
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