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EC number: 280-489-7 | CAS number: 83567-04-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From March 15, 1999 to March 18, 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- RA study
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Remarks:
- TOC determination
- Details on sampling:
- Analysis of the only test concentration plus a control at start and after 72 h of exposure
- Vehicle:
- no
- Remarks:
- direct weighing
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- Origin: Institute of Plant Physiology University of Göttingen
Conditions: in a light chamber et 23 +/- 2°C and with a quantum flux which equals 120 µE/m2.s
Initial cell density: 10,000 cells per mL - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
- Test temperature:
- 23 +/- 2°C
- pH:
- 8.3 - 10.3
- Nominal and measured concentrations:
- 0 and 100 mg/L (measured)
- Details on test conditions:
- Erlenweyer flasks (300 mL) with stoppers
100 mL of test medium
Light chamber and magnetic stirrer
Observations: growth and growth rate within a 72 h exposure period - Reference substance (positive control):
- no
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 84.8 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: growth and growth rate
- Remarks on result:
- other: 84.8 mg/L (organic components)
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 84.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- 84.8 mg/L of the organic components is equivalent to 103.4 mg/L of the test substance including the inorganic components
- Basis for effect:
- other: growth rate and biomass
- Details on results:
- Growth (integral of biomass): -16.3% (increase of growth)
Growth rate: -6.7% (increase of growth rate)
No toxic effects against algae at 84.8 mg/L of the organic components of the test substance (equals to 103.4 mg/L of the test substance including the inorganic components). - Results with reference substance (positive control):
- -
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the mean measured 72 h NOEC of the substance in Desmodesmus subspicatus was determined to be greater than 84.8 mg/L of the organic components (equivalent to 103.4 mg/L of the substance including inorganic components). The EC10 and EC50 could not be determined due to absence of adverse effects.
- Executive summary:
A study was conducted to determine the short-term toxicity of the read-across substance to aquatic algae and cyanobacteria according EU Method C.3, in compliance with GLP. Desmodesmus subspicatus were exposed for 72 h to the test substance at nominal concentrations of 0 and 100 mg/L. Growth rate and cell density were assessed at start and end of 72 h of exposure period. Analytical verification of test concentrations was conducted by TOC determination. The growth rate was determined to be -6.7%. No toxic effects against the algae were observed at the test substance concentration. Under the study conditions, the mean measured 72 h NOEC of the substance in Desmodesmus subspicatus was determined to be greater than 84.8 mg/L of the organic components (equivalent to 103.4 mg/L of the test substance including inorganic components) (Caspers, 1999). The EC10 and EC50 could not be determined due to absence of adverse effects.
Reference
Description of key information
Under the read-across study conditions, the mean measured 72 h NOEC of the substance in Desmodesmus subspicatus was determined to be greater than 84.8 mg/L of the organic components (equivalent to 103.4 mg/L of the test substance including inorganic components). The EC10 and EC50 could not be determined due to absence of any adverse effects.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 100 mg/L
Additional information
A study was conducted to determine the short-term toxicity of the read-across substance to aquatic algae and cyanobacteria according EU Method C.3, in compliance with GLP. Desmodesmus subspicatus were exposed for 72 h to the test substance at nominal concentrations of 0 and 100 mg/L. Growth rate and cell density were assessed at start and end of 72 h of exposure period. Analytical verification of test concentrations was conducted by TOC determination. The growth rate was determined to be -6.7%. No toxic effects against the algae were observed at the test substance concentration. Under the study conditions, the mean measured 72 h NOEC of the substance in Desmodesmus subspicatus was determined to be greater than 84.8 mg/L of the organic components (equivalent to 103.4 mg/L of the substance including inorganic components) (Caspers, 1999). The EC10 and EC50 could not be determined due to absence of any adverse effects.
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