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EC number: 201-815-6 | CAS number: 88-26-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 Jul - 18 Jul 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- LUBW Landesanstalt für Umwelt, Messungen und Naturschutz Baden-Württemberg, Karlsruhe, Germany
- Type of method:
- flask method
Test material
- Reference substance name:
- 3,5-di-tert-butyl-4-hydroxybenzyl alcohol
- EC Number:
- 201-815-6
- EC Name:
- 3,5-di-tert-butyl-4-hydroxybenzyl alcohol
- Cas Number:
- 88-26-6
- Molecular formula:
- C15H24O2
- IUPAC Name:
- 2,6-Di-tert-butyl-4-(hydroxymethyl)phenol
Constituent 1
- Specific details on test material used for the study:
- Storage conditions: ambient (5 to 30 °C), dark, dry
Results and discussion
Water solubility
- Water solubility:
- 22.95 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Temp.:
- 20 °C
- pH:
- 5.84
Any other information on results incl. tables
Results
Preliminary test
Table 3 – Preliminary test results (1sttest)
Test item [mg] |
Total volume of ultra-pure water [mL] |
Shaking time [min] |
Remarks |
Approx. solubility [g/L] |
100.2 |
0.1 |
10 |
Not completely dissolved |
< 1002 |
100.2 |
0.5 |
10 |
Not completely dissolved |
< 200.4 |
100.2 |
1 |
10 |
Not completely dissolved |
< 100.2 |
100.2 |
2 |
10 |
Not completely dissolved |
< 50.1 |
100.2 |
10 |
10 |
Not completely dissolved |
< 10.0 |
100.2 |
100 |
10 |
Not completely dissolved |
< 1.0 |
100.2 |
100 |
18 h |
Not completely dissolved |
< 1.0 |
100.2 |
100 |
23 h |
Not completely dissolved |
< 1.0 |
100.2 |
100 |
24 h |
Not completely dissolved |
< 1.0 |
Table 4 – Preliminary test results (2ndtest)
Test item [mg] |
Total volume of ultra-pure water [mL] |
Shaking time [min] |
Remarks |
Approx. solubility [mg/L] |
10.1 |
100 |
10 |
Not completely dissolved |
< 101 |
10.1 |
200 |
10 |
Not completely dissolved |
< 50.5 |
10.1 |
500 |
3 h |
Not completely dissolved |
< 20.2 |
10.1 |
1000 |
3 h |
Not completely dissolved |
10.1 – 20.2 |
10.1 |
1000 |
16 h |
Not completely dissolved |
10.1 – 20.2 |
10.1 |
1000 |
24 h |
Dissolved |
10.1 – 20.2 |
Main Test
Table 5 – Water Solubility results
Run time [h] |
Analyte concentration [mg/L] Flask 1 |
Analyte concentration [mg/L] Flask 2 |
Mean concentration [mg/L] |
pH value |
48 |
23.31 |
22.81 |
23.06 |
5.83 |
|
|
Mean |
22.95 |
5.84 |
Standard deviation |
2.70 |
0.02 |
||
Relative standard deviation [%] |
11.8 |
0.3 |
Conclusion
Water solubility of the test item was determined in ultra-pure water in
equilibrium with atmospheric carbon dioxide at a temperature of 20 ±0.5
°C.
Table 6 – Final results
Determined pH |
5.84 |
Temperature [°C] |
19.7 – 20.0 |
Mean solubility [mg/L] |
22.95 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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