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Diss Factsheets
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EC number: 203-656-8 | CAS number: 109-21-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Aliphatic alcohols and alkyl esters: Narcotic and lethal potencies to tadpoles and to rabbits.
- Author:
- Munch
- Year:
- 1 972
- Bibliographic source:
- Industrial Medicine and Surgery, 41(4), 31-33
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In the current study the narcotic potencies and lethal effetcs of aliphatic alcohols and their alkyl esters were assessed. A group of 10 - 35 male and female rabbits was treated with the test item. Administration of the test material was by stomach tube. The lethal dose (LD50) which was the quantity that caused death in 50% of the treated rabbits was also determined.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Butyl butyrate
- EC Number:
- 203-656-8
- EC Name:
- Butyl butyrate
- Cas Number:
- 109-21-7
- Molecular formula:
- C8H16O2
- IUPAC Name:
- butyl butanoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1.5 - 2.5 kg
- Fasting period before study: no
- Acclimation period: 2 weeks
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Not specified.
- No. of animals per sex per dose:
- 10 - 35 animals in total
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 9 518 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Based on the molecular weight of 144.21 g/mol and an LD50 value of 66 mmol/kg, an LD value of 9518 mg/kg was calculated.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was determined to be 9518 mg/kg.
- Executive summary:
In the current study the narcotic potencies and lethal effects of aliphatic alcohols and their alkyl esters were assessed. A group of 10 - 35 male and female rabbits was treated with the test item. Administration of the test material was by stomach tube.
The lethal dose (LD50) which was the quantity that caused death in 50% of the treated rabbits was also determined.
The LD50 was determined to be 9518 mg/kg. No other details or results were provided. However, according to the CLP Regulation the test item should not be classified.
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