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EC number: 606-630-8 | CAS number: 20765-98-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 March - 30 April 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP. It should be noted that this record was produced using an English translation of the study report that was written in German.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Rhodium (III) chloride hydrate
- IUPAC Name:
- Rhodium (III) chloride hydrate
- Reference substance name:
- 20765-98-4, 13465-43-5
- IUPAC Name:
- 20765-98-4, 13465-43-5
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Rhodium (III) chloride hydrate
- Substance type: No data
- Physical state: Dark red crystals
- Analytical purity: 99.5% (38.3% Rh)
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: Ir, 0.005%; Ag, 0.002%; Cu 0.001%; Ca, 0.005%; Mg, 0.002%; Si, 0.003%
- Isomers composition: Not applicable
- Purity test date: 18 February 1986
- Lot/batch No.: 27461
- Expiration date of the lot/batch: No data
- Stability under test conditions: According to information of the sponsor, the test substance was stable throughout the experimental period
- Storage condition of test material: Room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Savo Ivanovas med. , Versuchstierzuchten GmbH, D-7940 Kisslegg im Allgäu
- Age at study initiation: Males, 3-4 months; females, 2-4 months
- Weight at study initiation: Males, 2.75-3.00 kg; females, 2.15-2.75 kg
- Fasting period before study: On the day of treatment
- Housing: Individually housed in high-grade steel cages
- Diet (e.g. ad libitum): Ad libitum standard diet, ssniff K “special diet for rabbits” supplied by ssniff Spezialfutter GmbH, D-4770 Soest
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Animals kept for 5 days under test conditions before application of the test material
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22.5-23.5
- Humidity (%): 45-60
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Remarks:
- moistened with water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap if used: No data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, washed off with water
- Time after start of exposure: 24 hrs
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): No data
- Concentration (if solution): Not applicable
- Constant volume or concentration used: Not applicable
VEHICLE
- Amount(s) applied (volume or weight with unit): Not applicable
- Concentration (if solution): Not applicable
- Purity: Not applicable - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 3 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 21-27 days
- Frequency of observations and weighing: Observations 6-8 hours after application, then twice daily (once daily at weekends), body weights measured directly before, and 7 and 14 days after, application.
- Necropsy of survivors performed: Yes (Gross necropsy was performed on all animals that died during the course of the study and on surviving animals that were killed at the end of the observation period. External appearance, body orifices, body cavities (thoracic and abdominal) and their contents were examined macroscopically)
- Other examinations performed: Clinical signs, body weight - Statistics:
- Not applicable (Limit test acute dermal LD50)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One of the male rabbits died 3 days after application of the test material. No deaths were noted amongst the females.
- Clinical signs:
- other: One male was in poor general health (prior to death). No symptoms in the remaining animals.
- Gross pathology:
- In the male that died, observations included bleeding in the pelvic area and brittle bones as well as liver and kidney damage. Two hours after death, the blood still showed no tendency to coagulate.
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a guideline acute dermal toxicity study, conducted to GLP, the median lethal dose (LD50) of rhodium (III) chloride hydrate was found to exceed 2000 mg/kg bw following a 24-hour occlusive application in rabbits.
- Executive summary:
In an acute dermal limit test, conducted according to OECD Test guideline 402 and to GLP, 5 male and 3 female New Zealand White rabbits received a single dermal application of rhodium (III) chloride hydrate (moistened with water) at 2000 mg/kg bw for 24 hours (under occlusion).
A single male died at this dose 3 days after application, exhibiting reduced body weight as well as effects on the liver, kidney and blood. No toxicity was apparent in the remaining animals. The acute dermal median lethal dose (LD50) of rhodium (III) chloride hydrate is greater than 2000 mg/kg bw in rabbits.
Based on the results of this study, rhodium (III) chloride hydrate does not need classification for acute dermal toxicity according to EU CLP criteria (EC 1272/2008).
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