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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed document

Data source

Reference
Reference Type:
publication
Title:
METHYL NONELYNATE
Author:
D.L.J. Opdyke
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology. 14, 811

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study of Methyl nonylenate (CAS No: 111-79-5) was performed on human subjects to examine the adverse skin effects caused by the chemical under occlusive condition.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl non-2-enoate
EC Number:
203-908-7
EC Name:
Methyl non-2-enoate
Cas Number:
111-79-5
Molecular formula:
C10H18O2
IUPAC Name:
methyl non-2-enoate
Test material form:
liquid
Details on test material:
- Name of test material: methyl (2E)-non-2-enoate
- Molecular formula: C10H18O2
- Molecular weight: 170.25 g/mol
- Smiles notation: C(\C=C\C(OC)=O)CCCCC
- InChl: 1S/C10H18O2/c1-3-4-5-6-7-8-9-10(11)12-2/h8-9H,3-7H2,1-2H3/b9-8+
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material: Pyrazine-2-carboxylic acid
- Molecular formula: C5H4N2O2
- Molecular weight: 124.099 g/mol
- Substance type: organic
- Physical state: solid
- Smiles: c1ncc(C(=O)O)nc1
- InChI: 1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)

Test animals

Species:
human
Strain:
other: not applicable
Details on test animals or test system and environmental conditions:
No Data Available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: petrolatum
Controls:
not specified
Amount / concentration applied:
20% in petrolatum
Duration of treatment / exposure:
48hr
Observation period:
48hr
Number of animals:
25 volunteers
Details on study design:
No Data Available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No known signs of skin irritation were observed.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The test material Methyl nonylenate (CAS No: 111-79-5) was considered to be not irritating to the human skin.
Executive summary:

Skin irritation study of Methyl nonylenate (CAS No: 111-79-5) was performed on human subjects to examine the adverse skin effects caused by the chemical under occlusive condition.

 

About 20% of Methyl nonylenate in petrolatum was applied to the skin of each subject for 48 hours and later observed for skin reactions.

 

No known signs of skin irritation were observed. Hence the chemicalMethyl nonylenate (CAS No: 111-79-5)was considered to be not irritating to the human skin.