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EC number: 238-947-9 | CAS number: 14874-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Eye test carried out to guideline (US). Limited reporting, notably of test material (e.g. purity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: As described in US Federal Register 1973 Eye test.
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Affected animals terminated after 3 days - lesion progression/reversibility not assessed
- GLP compliance:
- no
- Remarks:
- Predates GLP
Test material
- Reference substance name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- EC Number:
- 238-947-9
- EC Name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- Cas Number:
- 14874-82-9
- Molecular formula:
- C7H7O4Rh
- IUPAC Name:
- Dicarbonyl(pentane-2,4-dionato-O,O')rhodium
- Details on test material:
- - Name of test material (as cited in study report): Rhodium Dicarbonyl Acetylacetonate
- Substance type: Dark coloured metallic powder
- Physical state: Solid
- Lot/batch No.: 61078/XX
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: "Recognised breeders"
- Age at study initiation: 14-16 weeks
- Weight at study initiation: 2.2 kg
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: right eye treated; left eye untreated - control
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- up to 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
SCORING SYSTEM: Draize method - corneal opacity, iris inflammation, conjunctival irritation
TOOL USED TO ASSESS SCORE: hand-slit lamp
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- corrected cumulative score
- Time point:
- other: 24, 48, 72 hours
- Score:
- 6.4
- Max. score:
- 80
- Reversibility:
- not specified
- Remarks on result:
- other: See Tables 1 and 2
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- corrected cumulative score
- Time point:
- other: 24, 48, 72 hours
- Score:
- 2.5
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- other: See Tables 1 and 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- corrected cumulative score
- Time point:
- other: 24, 48, 72 hours
- Score:
- 7.5
- Max. score:
- 20
- Reversibility:
- not specified
- Remarks on result:
- other: See Tables 1 and 2
- Irritant / corrosive response data:
- Corneal damage was seen in two of the treated animals at all time points, and in an additional animal at 72 hours. Effects on the iris of four animals was seen at 24 hours but in only two animals at 72 hours. All 6 animals showed redness to the conjunctivae after 24 and 48 hours, the effect also being seen in 5/6 animals at 72 hours. Chemosis and conjunctival discharge was seen in three animals at all time points examined and in one (chemosis) and two (discharge) at 24 hours only. See Table 1 for total and average scores.
- Other effects:
- No data
Any other information on results incl. tables
Table 1. Individual scores for the group of 6 rabbits
No. | Time/hr | Cornea | Iris | Conjunctivae | Corrected score | Total | ||||||
O | A | R | Ch. | Dis. | Cr. | Ir. | Cj. | |||||
1 | 24 | 1 | 4 | 1 | 1 | 2 | 3 | 20 | 5 | 12 | 37 | |
48 | 2 | 2 | 1 | 2 | 1 | 1 | 20 | 5 | 8 | 33 | ||
72 | 1 | 4 | 0 | 1 | 2 | 2 | 20 | 0 | 10 | 30 | ||
2 | 24 | 0 | 0 | 0 | 2 | 1 | 2 | 0 | 0 | 10 | 10 | |
48 | Dull | Dull | 0 | 2 | 0 | 0 | 0 | 0 | 4 | 4 | ||
72 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 2 | ||
3 | 24 | 0 | 0 | 1 | 2 | 0 | 1 | 0 | 5 | 6 | 11 | |
48 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 2 | ||
72 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 2 | ||
4 | 24 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4 | 4 | |
48 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 2 | ||
72 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
5 | 24 | 0 | 0 | 1 | 2 | 2 | 2 | 0 | 5 | 12 | 17 | |
48 | Dull | Dull | 1 | 3 | 2 | 1 | 0 | 5 | 12 | 17 | ||
72 | 1 | 2 | 1 | 2 | 2 | 2 | 0 | 5 | 12 | 17 | ||
6 | 24 | 1 | 3 | 1 | 2 | 3 | 2 | 15 | 5 | 14 | 34 | |
48 | 1 | 3 | 1 | 3 | 2 | 1 | 15 | 5 | 12 | 32 | ||
72 | 1 | 3 | 1 | 1 | 2 | 2 | 15 | 5 | 10 | 30 |
O: Opacity; A: Area; R: Redness; Ch.: Chemosis; Dis.: Discharge; Cr.: Cornea; Ir.: Iris; Cj.: Conjunctivae
Table 2. Total and average score for the group of 6 rabbits
Time | Cornea | Iris | Conjunctivae | Total | |
24 hours | 35 | 20 | 59 | 114 | |
48 hours | 35 | 15 | 40 | 90 | |
72 hours | 45 | 10 | 36 | 91 | |
Total | 115 | 45 | 135 | 295 | |
Average | 19.2 | 7.5 | 22.5 | 49.2 |
All 6 rabbits showed a positive response
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- In an in vivo eye irritation study, undiluted rhodium dicarbonyl acetylacetonate (0.1 g) produced eye irritation in all six treated albino rabbits, following a 72-hr observation period. The reversibility of the lesions (after 21 days) was not investigated, though the general trend in the irritation scores suggests classification as an eye irritant (category 2) is appropriate.
- Executive summary:
In a US guideline in vivo eye irritation study, undiluted rhodium dicarbonyl acetylacetonate (0.1 g) was instilled into the right eye of 6 female New Zealand white rabbits. The animals were assessed for signs of irritation after 24, 48 and 72 hr and the data scored according to the Draize method. The eyes of the treated animals were not rinsed at any time and no observations beyond 72 hours were made.
Corneal damage was seen in two of the treated animals at all observation points, and in an additional animal at 72 hr. Effects on the iris of four animals was seen at 24 hours but in only two animals at 72 hours. All 6 animals showed redness to the conjunctivae after 24 and 48 hours, the effect also being seen in 5/6 animals at 72 hours. Chemosis and conjunctival discharge was seen in three animals at all time points examined and in one (chemosis) and two (discharge) at 24 hours only.
The reversibility of the lesions (after 21 days) was not investigated. However, the iris and conjunctivae scores showed a general decrease over the three time periods. While the corneal scores were slightly increased at 72 hr due to reactions in a single animal, effects were consistent across the time points in two animals and no corneal effects were observed in the remaining three animals at any time point.
The investigators concluded that as all 6 treated animals showed a positive response to the test material it would be classified as an eye irritant according to the US Federal register 1973 Eye Test.
All six rabbits showed respective scores for iritis and corneal opacity of less than 1.5 and 3. While the observation period was limited to 3 days (OECD guideline recommends 21 days), there is sufficient evidence to indicate a general reversibility in the observed effects. As such, classification of rhodium dicarbonyl acetylacetonate as an eye irritant (category 2), is appropriate on the basis of the findings of this study and according to EU CLP criteria (EC 1272/2008).
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