Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-348-8 | CAS number: 81-42-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity
LD50 was estimated to be 875.122 mg/kg bw, when male Sprague-Dawley rats were exposed with 1,4-diamino-2,3-dichloroanthraquinone (81-42-5) orally.
Acute dermal toxicity
LD50 was estimated to be 9260.18mg/kg bw. When male and female New Zealand White rabbits were exposed with 1,4-diamino-2,3-dichloroanthraquinone (81-42-5) by dermal application.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR toolbox v3.3 and the QMRF report has been attached.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Prediction was done using OECD QSAR toolbox v3.3, 2017
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- Name of the test chemical: 1,4-diamino-2,3-dichloroanthraquinone
Molecular formula: C14H8Cl2N2O2
Molecular weight: 307.135 g/mol
Smiles Notation: c1cc2c(cc1)C(=O)c1c(c(c(c(c1N)Cl)Cl)N)C2=O
InChI: 1S/C14H8Cl2N2O2/c15-9-10(16)12(18)8-7(11(9)17)13(19)5-3-1-2-4-6(5)14(8)20/h1-4H,17-18H2
Substance Type: Organic
Physical State: Solid crystal powder (purple-black) - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data available
- Doses:
- 875.122mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 875.122 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 was estimated to be 875.122 mg/kg bw, when male Sprague-Dawley rats were exposed with 1,4-diamino-2,3-dichloroanthraquinone (81-42-5) orally.
- Executive summary:
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for 1,4-diamino-2,3-dichloroanthraquinone(81-42-5) ,LD50 was estimated to be 875.122 mg/kg bw, when male Sprague-Dawley ratswereexposed with 1,4-diamino-2,3-dichloroanthraquinone(81-42-5)orally.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LD50
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((((("a"
or "b" )
and ("c"
and (
not "d")
)
)
and ("e"
and (
not "f")
)
)
and ("g"
and (
not "h")
)
)
and "i" )
and ("j"
and (
not "k")
)
)
and ("l"
and (
not "m")
)
)
and ("n"
and (
not "o")
)
)
and ("p"
and "q" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Aminoaniline, para OR
Anthracenone/ Antracendione OR Aryl halide OR Overlapping groups by
Organic Functional groups (nested) ONLY
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Amine OR Aromatic compound OR
Aryl chloride OR Aryl halide OR Carbonyl compound OR Halogen derivative
OR Ketone OR Primary amine OR Primary aromatic amine by Organic
functional groups, Norbert Haider (checkmol) ONLY
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Michael addition OR Michael
addition >> P450 Mediated Activation to Quinones and Quinone-type
Chemicals OR Michael addition >> P450 Mediated Activation to Quinones
and Quinone-type Chemicals >> Arenes OR Michael addition >> P450
Mediated Activation to Quinones and Quinone-type Chemicals >> Polycyclic
(PAHs) and heterocyclic (HACs) aromatic hydrocarbons-Michael addition OR
Michael addition >> Polarised Alkenes-Michael addition OR Michael
addition >> Polarised Alkenes-Michael addition >> Alpha, beta-
unsaturated ketones OR SN1 OR SN1 >> Carbenium Ion Formation OR SN1 >>
Carbenium Ion Formation >> Polycyclic (PAHs) and heterocyclic (HACs)
aromatic hydrocarbons-SN1 OR SN1 >> Nitrenium Ion formation OR SN1 >>
Nitrenium Ion formation >> Primary aromatic amine OR SN2 OR SN2 >>
Direct Acting Epoxides and related OR SN2 >> Direct Acting Epoxides and
related >> Epoxides OR SN2 >> Epoxidation of Aliphatic Alkenes OR SN2 >>
Epoxidation of Aliphatic Alkenes >> Halogenated polarised alkenes by DNA
binding by OECD
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OASIS v1.3
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Ester
aminolysis OR Acylation >> Ester aminolysis >> Amides OR Michael
Addition OR Michael Addition >> alpha,beta-Unsaturated carbonyl
compounds OR Michael Addition >> alpha,beta-Unsaturated carbonyl
compounds >> alpha,beta-Aldehydes OR Michael Addition >> Michael
addition on conjugated systems with electron withdrawing group OR
Michael Addition >> Michael addition on conjugated systems with electron
withdrawing group >> alpha,beta-Carbonyl compounds with polarized double
bonds OR Michael Addition >> Polarised Alkenes OR Michael Addition >>
Polarised Alkenes >> Polarised Alkene - alkenyl pyridines, pyrazines,
pyrimidines or triazines OR Michael Addition >> Quinoide type compounds
OR Michael Addition >> Quinoide type compounds >> Quinone
methide(s)/imines; Quinoide oxime structure; Nitroquinones,
Naphthoquinone(s)/imines OR Nucleophilic addition OR Nucleophilic
addition >> Addition to carbon-hetero double bonds OR Nucleophilic
addition >> Addition to carbon-hetero double bonds >> Ketones OR Schiff
base formation OR Schiff base formation >> Direct acting Schiff base
formers OR Schiff base formation >> Direct acting Schiff base formers >>
1,2-Dicarbonyls and 1,3-Dicarbonyls OR Schiff base formation >> Schiff
base formation with carbonyl compounds OR Schiff base formation >>
Schiff base formation with carbonyl compounds >> Aldehydes OR SNAr OR
SNAr >> Nucleophilic aromatic substitution on activated aryl and
heteroaryl compounds OR SNAr >> Nucleophilic aromatic substitution on
activated aryl and heteroaryl compounds >> Activated aryl and heteroaryl
compounds OR SNVinyl OR SNVinyl >> SNVinyl at a vinylic (sp2) carbon
atom OR SNVinyl >> SNVinyl at a vinylic (sp2) carbon atom >> Vinyl type
compounds with electron withdrawing groups by Protein binding by OASIS
v1.3
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group All Lipid
Solubility < 0.01 g/kg AND (!Undefined)Group CNHal Lipid Solubility <
400 g/kg AND Group All Melting Point > 200 C AND Group CNHal Aqueous
Solubility < 0.004 g/L AND Group CNHal Aqueous Solubility < 0.1 g/L AND
Group CNHal log Kow > 3.8 by Eye irritation/corrosion Exclusion rules by
BfR
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as (!Undefined)Group CN Lipid
Solubility < 0.4 g/kg OR Group All Aqueous Solubility < 0.000005 g/L OR
Group All Aqueous Solubility < 0.00002 g/L OR Group All log Kow > 9 OR
Group All Molecular Weight > 650 g/mol OR Group C Aqueous Solubility <
0.0001 g/L OR Group C Aqueous Solubility < 0.0005 g/L OR Group C Melting
Point > 55 C OR Group CN Aqueous Solubility < 0.1 g/L OR Group CN log
Kow > 4.5 OR Group CN Molecular Weight > 290 g/mol OR Group CNHal
Molecular Weight > 370 g/mol OR Group CNS log Kow > 1.5 OR Group CNS
Melting Point > 50 C by Eye irritation/corrosion Exclusion rules by BfR
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Not categorized by Repeated dose
(HESS)
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Aromatic hydrocarbons (Liver
enzyme induction) Rank C OR Chlorphentermine (Hepatotoxicity) Alert OR
Halobenzenes (Hepatotoxicity) Rank A OR Halobenzenes (Renal toxicity)
Rank A OR Halogenated aliphatic compounds (Hepatotoxicity) Rank A OR
Tamoxifen (Hepatotoxicity) Alert by Repeated dose (HESS)
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as No alert found by rtER Expert
System ver.1 - USEPA
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Phenones (Branched) by rtER
Expert System ver.1 - USEPA
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Non binder, impaired OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Non binder, non cyclic structure
by Estrogen Receptor Binding
Domain
logical expression index: "p"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 3.84
Domain
logical expression index: "q"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 4.89
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 875.122 mg/kg bw
- Quality of whole database:
- Data is Klimicsh 2 and from QSAR Toolbox 3.3. (2017)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR toolbox v3.3 and the QMRF report has been attached.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Prediction was done using OECD QSAR toolbox v3.3, 2017
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
- Specific details on test material used for the study:
- Name of the test chemical: 1,4-diamino-2,3-dichloroanthraquinone
Molecular formula: C14H8Cl2N2O2
Molecular weight: 307.135 g/mol
Smiles Notation: c1cc2c(cc1)C(=O)c1c(c(c(c(c1N)Cl)Cl)N)C2=O
InChI: 1S/C14H8Cl2N2O2/c15-9-10(16)12(18)8-7(11(9)17)13(19)5-3-1-2-4-6(5)14(8)20/h1-4H,17-18H2
Substance Type: Organic
Physical State: Solid crystal powder (purple-black) - Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 9260.18mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 9 260.18 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- No data available
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was estimated to be 9260.18mg/kg bw. When male and female New Zealand White rabbits were exposed with 1,4-diamino-2,3-dichloroanthraquinone (81-42-5) by dermal application.
- Executive summary:
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for 1,4-diamino-2,3-dichloroanthraquinone(81-42-5),LD50 was estimated to be 9260.18mg/kg bw. When male and female NewZealand Whiterabbits wereexposed with 1,4-diamino-2,3-dichloroanthraquinone(81-42-5)by dermal application.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(((((((((("a"
or "b" )
and ("c"
and (
not "d")
)
)
and ("e"
and (
not "f")
)
)
and "g" )
and ("h"
and (
not "i")
)
)
and ("j"
and (
not "k")
)
)
and ("l"
and (
not "m")
)
)
and "n" )
and ("o"
and (
not "p")
)
)
and ("q"
and "r" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Aminoaniline, para OR
Anthracenone/ Antracendione OR Aryl halide OR Overlapping groups by
Organic Functional groups (nested) ONLY
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Amine OR Aromatic compound OR
Aryl chloride OR Aryl halide OR Carbonyl compound OR Halogen derivative
OR Ketone OR Primary amine OR Primary aromatic amine by Organic
functional groups, Norbert Haider (checkmol) ONLY
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Not possible to classify
according to these rules by DPRA Cysteine peptide depletion
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as High reactive OR High reactive
>> alpha,beta-carbonyl compounds with polarized multiple bonds OR High
reactive >> Vinyl pyridines OR Low reactive OR Low reactive >> Alicyclic
ketones OR Low reactive >> alpha-alkyl cinnamaldehyde derivatives OR
Moderate reactive OR Moderate reactive >> Activated 1,3,5-triazine
derivatives OR Moderate reactive >> Glycidyl ether epoxides OR Moderate
reactive >> Phenyl substituted cinnamaldehydes by DPRA Cysteine peptide
depletion
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as No alert found by Protein
binding by OECD
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Michael addition OR Michael
addition >> Polarised Alkenes OR Michael addition >> Polarised Alkenes
>> Polarised alkene - ketones OR Michael addition >> Quinones and
Quinone-type Chemicals OR Michael addition >> Quinones and Quinone-type
Chemicals >> Quinone-methides OR Schiff Base Formers OR Schiff Base
Formers >> Direct Acting Schiff Base Formers OR Schiff Base Formers >>
Direct Acting Schiff Base Formers >> 1-3-Dicarbonyls by Protein binding
by OECD
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Halogens AND Non-Metals by
Groups of elements
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Metalloids by Groups of elements
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Group 14 - Carbon C AND Group 15
- Nitrogen N AND Group 16 - Oxygen O AND Group 17 - Halogens Cl AND
Group 17 - Halogens F,Cl,Br,I,At by Chemical elements
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Group 15 - Phosphorus P by
Chemical elements
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Not categorized by Repeated dose
(HESS)
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as 3-Methylcholantrene
(Hepatotoxicity) Alert OR Amineptine (Hepatotoxicity) Alert OR Anilines
(Hemolytic anemia with methemoglobinemia) Rank A OR Anilines
(Hepatotoxicity) Rank C OR Aromatic hydrocarbons (Liver enzyme
induction) Rank C OR Chlorphentermine (Hepatotoxicity) Alert OR
Halobenzenes (Hepatotoxicity) Rank A OR Halobenzenes (Renal toxicity)
Rank A by Repeated dose (HESS)
Domain
logical expression index: "n"
Similarity
boundary:Target:
Nc1c(Cl)c(Cl)c(N)c2c1C(=O)c1ccccc1C2=O
Threshold=50%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Not categorized by OECD HPV
Chemical Categories
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as C9 Aromatics hydrocarbon
solvents OR Xylenes by OECD HPV Chemical Categories
Domain
logical expression index: "q"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 3.03
Domain
logical expression index: "r"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 4.9
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 9 260.18 mg/kg bw
- Quality of whole database:
- Data is Klimicsh 2 and from QSAR Toolbox 3.3. (2017)
Additional information
Acute oral toxicity
In different studies, 1,4-diamino-2,3-dichloroanthraquinone(81-42-5)has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for 1,4-diamino-2,3-dichloroanthraquinone(81-42-5). The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for 1,4-diamino-2,3-dichloroanthraquinone(81-42-5) ,LD50 was estimated to be 875.122 mg/kg bw, when male Sprague-Dawley ratswereexposed with 1,4-diamino-2,3-dichloroanthraquinone(81-42-5)orally.
In experimental study given by U.S .National library of medicine (ChemID plusA TOXNET DATABASE.2017) on structurally similar read across substance 4-Amino-4-chloroanthraquinone (2872-47-1). In acute oral toxicity study, mice were treated with4-Amino-4-chloroanthraquinoneorally. 50% mortality was observed in treated mouse at 1320 mg/kg bw. Therefore, LD50 was considered to be 1320 mg/kg bw When mouse were treated with 4-Amino-4-chloroanthraquinone (2872-47-1) orally.
Also it is further supported by experimental study given by U.S .National library of medicine (ChemID plusA TOXNET DATABASE.2017) on structurally similar read across substance 1,4-Diamino-2-methoxyanthraquinone(2872-48-2) .In
In acute oral toxicity study, rats were treated with1,4-Diamino-2-methoxyanthraquinone orally. 50% mortality was observed in treated rats at 891 mg/kg bw. Clinical signs like Behavioural changes as somnolence (general depressed activity) and gastrointestinal changes on kidney, ureter, and bladder were observed .Also changes in urine composition were noted in treated rats. Therefore, LD50 was considered to be 891mg/kg bw. When rats were treated1,4-Diamino-2-methoxyanthraquinone(2872-48-2) orally.
Thus, based on the above studies and predictions on 1,4-diamino-2,3-dichloroanthraquinone(81-42-5)and its read across substances, it can be concluded that LD50 value is less than875.122 mg/kg bw. Thus, comparing this value with the criteria of CLP regulation 1,4-diamino-2,3-dichloroanthraquinone(81-42-5)can be classified as“Category IV”for acute oral toxicity.
Acute dermal toxicity
In different studies,1,4-diamino-2,3-dichloroanthraquinone(81-42-5)has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rabbits for1,4-diamino-2,3-dichloroanthraquinone(81-42-5),The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for 1,4-diamino-2,3-dichloroanthraquinone(81-42-5),LD50 was estimated to be 9260.18mg/kg bw. When male and female New Zealand White rabbits were exposed with 1,4-diamino-2,3-dichloroanthraquinone(81-42-5)by dermal application.
Also it is further supported by experimental study given by U.S .National library of medicine (ChemID plusA TOXNET DATABASE.2017) on structurally similar read across substance1,3-Diisopropenylbenzene (3748-13-8).Acute dermal toxicity study was done in rabbits using test material1,3-Diisopropenylbenzene.No mortality was observed at dose 2000mg/kg bw. HenceLD50 was considered to be >2000mg/kg body weight. When rabbits were treated with 1,3-Diisopropenylbenzene (3748-13-8) by dermal application.
Also it is further supported by experimental study given by U.S .National library of medicine (ChemID plusA TOXNET DATABASE.2017) on structurally similar read across substance1,4-Diamino-2-methoxyanthraquinone(2872-48-2).In acute dermal toxicity study, rabbits were treated with1,4-Diamino-2-methoxyanthraquinoneby dermal application . No mortality was observed in treated rabbits at 2000 mg/kg bw. Clinical signs like the skin after systemic exposure causes dermatitis and other changes in skin and appendages were observed. Also effect on kidney, ureter, and bladder and changes in urine composition were noted .Therefore, LD50 was considered to be>2000mg/kg bw. When rabbits were treated1,4-Diamino-2-methoxyanthraquinone(2872-48-2) by dermal application.
Thus, based on the above studies and predictions on1,4-diamino-2,3-dichloroanthraquinone(81-42-5)and its read across substances, it can be concluded that LD50 value is 9260.18mg/kg bw. Thus, comparing this value with the criteria of CLP1,4-diamino-2,3-dichloroanthraquinone(81-42-5)can be “Not classified” for acute dermal toxicity.
Justification for classification or non-classification
Thus, comparing this value with the criteria of CLP1,4-diamino-2,3-dichloroanthraquinone(81-42-5)can be
classified as“Category IV”for acute oral toxicity and “Not classified” for acute dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.