Registration Dossier
Registration Dossier
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EC number: 238-906-5 | CAS number: 14846-08-3
Endpoint summary
Administrative data
Description of key information
Adsorption/desorption:
The Soil Adsorption Coefficient i.e Koc value of sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS No: 14846-08-3) was estimated using EPI suite KOCWIN Program (v2.00) as 144.2 L/kg(log Koc=2.1589) by means of MCI method at 25 deg.C. This Koc value indicates that the substance sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate has low sorption to soil and sediment and therefore have moderate migration potential to groundwater.
Additional information
Adsorption/desorption:
Results of two different predicted data for the target compound of sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS No: 14846-08-3) and supporting weight of evidence study for its read across chemical were reviewed for the Adsorption end point which are summarized as below.
The Soil Adsorption Coefficient i.e Koc value of sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS No: 14846-08-3) was estimated using EPI suite ( Estimation Program Interface, 2017) KOCWIN Program (v2.00) as 144.2 L/kg(log Koc=2.1589) by means of MCI method at 25 deg.C. This Koc value indicates that the substance sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate has low sorption to soil and sediment and therefore have moderate migration potential to groundwater.
Another predicted Soil Adsorption Coefficient i.e Koc value of test substance sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS no. 14846 -08 -3) was estimated using Adsorption Coefficient module (v12.1.0.50374) program of ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017) over entire pH scale i.e., 1-14 as Koc 1 dimensionless (log Koc= 0). This log Koc value indicates that the test substance sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate has negligible sorption to soil and sediment and therefore have rapid migration potential to groundwater.
In a supporting weight of evidence Soil Adsorption/Mobility study was conducted for the read across chemical 4-aminobenzene-1-sulfonic acid (CAS no.121 -57 -3) to estimated Koc value by using Structure estimation method based on molecular connectivity indices. The estimated Koc value is 10 dimensionless and log Koc is 1 this log Koc value suggests that 4-aminobenzene-1-sulfonic acid is expected to have negligible sorption to soil and sediment and therefore have rapid migration potential to ground water.
On the basis of above results for target chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS No: 14846-08-3)(from EPI suite and ACD labs, 2017) and for its read across chemicals (From authoritative database HSDB) it can be concluded that the log Koc value of test substance sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate ranges from 0 to 2.15 indicating that the chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate has negligible to low sorption to soil and sediment and therefore have rapid to moderate migration potential to ground water
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