Registration Dossier
Registration Dossier
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EC number: 228-589-1 | CAS number: 6300-50-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17-02-2017 to 31-03-2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- yes
- Remarks:
- Calculation method
- Principles of method if other than guideline:
- The test substance contains as a main component disodium 7-amino-4-hydroxy-3-[[4-[( 4-sulphonatophenyl)azo ]phenyl]azo ]naphthalene-2-sulphonate. Owing to this substance is ionisable, it was no possible to strictly apply the OECD guideline to study its partition coefficient n-octanol/water.
For this reason both theoretical and experimental estimation were calculated applying ACD-Labs-5 software and the definition P o/w = C n-octanol / C water, at equilibrium and at controlled room temperature, respectively. - GLP compliance:
- no
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: weighed residues in n-octanol and water
- Key result
- Type:
- log Pow
- Partition coefficient:
- -1.68
- Temp.:
- 22 °C
- pH:
- 7.6
- Key result
- Type:
- Pow
- Partition coefficient:
- 0.021
- Temp.:
- 22 °C
- pH:
- 7.6
- Conclusions:
- The calculated log P o/w of the test substance is -1.68.
Reference
Description of key information
The value of the partition coefficient has been estimated from the solubility of the test substances in the pure solvents.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.68
- at the temperature of:
- 22 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
