Registration Dossier
Registration Dossier
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EC number: 264-859-5 | CAS number: 64381-99-3
Endpoint summary
Administrative data
Description of key information
BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical. The bioconcentration factor (BCF) of test chemical was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
Additional information
Various predicted data for the target compoundand supporting weight of evidence study for its read across substance were reviewed for the bioaccumulation end point which are summarized as below:
In aprediction done using theBCFBAF Program(v3.01) of Estimation Programs Interface (EPI Suite, 2017), the bioconcentration factor (BCF) of test chemical was estimated to be 3.162 L/kg whole body w.w (at 25 deg C).
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance was estimated to be 66 dimensionless . The predicted BCF result is based on the 5 OECD principles.
In a supporting weight of evidence study from authoritative database (J-CHECK, 2017) for the test chemical,
Long term studies was conducted to understand the potential of test chemical to get bioaccumulate in fresh water fish cyprinus caprio by following “the Notice on the Test Method Concerning New Chemical Substances" guidelines. The study was conducted for the period of 6 weeks in flow through system. Fishes was exposed to concentrations of 0.1mg/l and 0.01mg/l, Analytical monitoring results showed that test chemical in the exposure vessels for both concentrations was in range of 93-95%. After the exposure duration of 42, bioconcentration factor (BCF) was determined to be ≤0.2 l/kg and ≤1.7 L/kg at concentration of 0.1 and 0.01 mg/L, respectively. Based on the overall values obtained, the test chemical is not expected to get bioaccumulate in the aquatic animals
On the basis of above results for test chemical(from EPI suiteand CompTox Chemistry Dashboard, 2017) and for its weight of evidence(from authoritative database J-CHECK, 2107), it can be concluded that the BCF value of test substanceranges from 3.162 – 66 which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.
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