Sulphoacetic acid

Endpoint summary

Description of key information

Short-term toxicity to fish

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Sulphoacetic acid (CAS no.123-43-3) the effects observed in a static freshwater system. The lethal concentration LC50 value for the Sulphoacetic acid (CAS no.123-43-3) was estimated to be 442000 mg/l for fish for 96 hr exposure duration. Based on this lethal value it can be concluded that the Sulphoacetic acid (CAS no.123-43-3) is likely to be non toxic to aquatic environment and thus it can be considered as not classified as per the CLP classification criteria.

Short-term toxicity to aquatic invertebrates

Short term toxicity to aquatic invertebrates was carried out to study the effects of Sulphoacetic acid. The Effective concentration EC50 to 50% of Daphnia Magna is 809 mg/L for 24 hrs at which immobility was observed.

On the basis of the value obtained it can be concluded that the Sulphoacetic acid is not toxic to Daphnia Magna at environmentally relevant concentrations and can be considered as “not classified” under CLP regulation.

Toxicity to aquatic algae and cyanobacteria

Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the toxicity to Pseudokirchneriella subcapitata for Sulphoacetic acid (Cas no.123-43-1). EC50 value was estimated 155.50 mg/kg bw for Pseudokirchneriella subcapitata. Based on this value it can be concluded that the Sulphoacetic acid (Cas no.123-43-1) is considered to "non-toxic" to the aquatic invertebrates as per the criteria mentioned in CLP regulation

 

Additional information

Short-term toxicity to fish

Three studies of predicted data from validated tools and authorative database for toxicity to aquatic algae endpoint of test chemicalSulphoacetic acid(Cas no. 123-43-1) were summarised as follows:

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Sulphoacetic acid (CAS no.123-43-3) the effects observed in a static freshwater system. The lethal concentration LC50 value for the Sulphoacetic acid (CAS no.123-43-3) was estimated to be 442000 mg/l for fish for 96 hr exposure duration.

Another prediction done by Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for Sulphoacetic acid (CAS no.123-43-3) the effects observed in a static saltwater system. The lethal concentration LC50 value for the Sulphoacetic acid (CAS no.123-43-3) was estimated to be 547000 mg/l for fish for 96 hr exposure duration.

Using Battery algorithm model of Danish QSAR Short-term toxicity toFathead minnowfor Sulphoacetic acidestimated to beLC506758.767mg/L at 96 hrs.

Thus based on the effect concentrations which is in the range 6758.767 mg/l to 547000 mg/l give the conclusion that test substance Sulphoacetic acid (Cas no. 123-43-was likely to be non-toxic to fish at environmentally relevant concentrations and can be considered to be not classified as per the CLP classification criteria.

Short-term toxicity to aquatic invertebrates

Six studies including predicted data from validated tools and experimental data from peer reviewed journal for toxicity to aquatic algae endpoint of test chemical sulfoacetic acid (123-43-3) with relevant read across which is close to target using log Kow as primary descriptor were summarised as follows:

 

Experimental data from peer reviewed journalWater Research1978 suggests that the Short term toxicity to aquatic invertebrates was carried out to study the effects of Sulphoacetic acid.

The Effective concentration EC50 to 50% of Daphnia Magna is 809 mg/L for 24 hrs at which immobility was observed.

 

Above results is supported by prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the toxicity to Daphnia magna for Sulphoacetic acid (CAS no.123-43-3) EC50 value was estimated 205.95 mg/kg bw for Daphnia magna.

 

In another prediction by Using the EPI Suite ECOSAR version 1.11, the short term toxicity on Daphnia magna was estimated for Sulphoacetic acid (CAS no. 123-43-3) on the basis of the effects observed in a freshwater system. The lethal concentration LC50 value for Sulphoacetic acid (CAS no. 123-43-3) estimated to be 192000 mg/l for daphnia magna for 48 hrs. exposure duration.

 

Another prediction done Using Battery algorithm model of Danish QSAR Short-term toxicity to Daphnia magna forSulphoacetic acid estimated to beEC50 1606.093 mg/L at 48 hrs.

All above prediction results for target are further supported by experimental data of read across chemicalMalonic acid(Cas no. 123-43-3). The effective concentration EC50 value forDaphnia magna when exposed to Malonic acid for 48 Hour is275 mg/l. on the basis of obtained value it can be concluded that Malonic acid is not considered as toxic toDaphnia magnaat environmentally relevant concentrations.

 

Another experimental data of read across substanceSuccinic acid (110-15-6) from Journal of the Water Pollution Control Federation 1980 also indicates that the Effective concentration to 50% organisms (EC50) for Daphnia magna is 374.2 mg/l based on immobilisation effects.

Thus based on the effect concentrations which is in the range 205.95 mg/l to 2850000 give the conclusion that test substance Sulphoacetic acid (CAS no. 123-43-3) was likely to be non-toxic to aquatic algae at environmentally relevant concentrations and can be considered to be“not classified”as per the CLP classification criteria.

Toxicity to aquatic algae and cyanobacteria

Five studies including predicted data from validated tools and experimental data from secondary source

for toxicity to aquatic algae endpoint of test chemicalSulphoacetic acid(Cas no.123-43-3) with relevant read across which is close to target using log Kow as primary descriptor were

summarised as follows:

 

Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the toxicity to Pseudokirchneriella subcapitata for Sulphoacetic acid (Cas no.123-43-1). EC50 value was estimated 155.50 mg/kg bw for Pseudokirchneriella subcapitata. Based on this value it can be concluded that the Sulphoacetic acid (Cas no.123-43-1) is considered to "non-toxic" to the aquatic invertebrates as per the criteria mentioned in CLP regulation.

 

Similar prediction by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program suggestthat the 96 hours EC50 was estimated to be 47764 mg/l on algae for Sulphoacetic acid with growth inhibition effects.

 

Also prediction for target by Danish QSAR database, using the three different models i.e, Battery, Leadscope and SciQSAR within Danish QSAR database, indicates thatUsing Battery algorithm model of Danish QSAR Short-term toxicity to Pseudokirchneriella subcapitata for Sulphoacetic acidestimated to be EC50= 13510.7mg/L at 72 hrs.

All predicted results for target assisted by experimental data of read across chemical Cerium dioxide (1306-38-3) from TOXICOLOGICAL SCIENCES 2011 suggests that theEffective concentration to 50% of Anabaena sp. Is >100 mg/L at 24 h. On the basis of value obtained it can be concluded that the Cerium dioxide is not toxic to cyanobacterium Anabaena sp.

Another experimental data of read acrossTitanium dioxide (13463-67-7)from Chemical Engineering Journa 2011 indicates that the No observable effect concentration for Chlorella sp. Is 1000 mg/l at which no significant effect were observed.

Thus based on the effect concentrations which is in the range > 100 mg/l to 47764give the conclusion that test substanceSulphoacetic acid(Cas no.123-43-1) was likely to be non-toxic to aquatic algae at environmentally relevant concentrations and can be considered to be not classified as per the CLP classification criteria.