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EC number: 281-619-5 | CAS number: 84000-63-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from review artcle and safety assessment report
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Ethylenebis(tetrabromophthalimide) [CASRN 32588-76-4] Review of Toxicological Literature
- Author:
- NTP; National Institute of Environmental Health Sciences
- Year:
- 1 999
- Bibliographic source:
- NTP; National Institute of Environmental Health Sciences; October 1999
- Reference Type:
- secondary source
- Title:
- ACUTE EYE IRRITATION TEST IN RABBITS WITH ATTACHMENTS AND COVER LETTER DATED 030890
- Author:
- NTRL REPORT
- Year:
- 1 990
- Bibliographic source:
- NTRL REPORT - OTS0522916; 13 MARCH 1990
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- An eye irritation study of Ethylenebis(tetrabromophthalimide) (CAS No: 32588-76-4) was conducted on New Zealand albino rabbits to determine the degree of irritation produced by the test substance .
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,2'-ethane-1,2-diylbis(4,5,6,7-tetrabromo-1H-isoindole-1,3(2H)-dione)
- Cas Number:
- 32588-76-4
- Molecular formula:
- C18H4Br8N2O4
- IUPAC Name:
- 2,2'-ethane-1,2-diylbis(4,5,6,7-tetrabromo-1H-isoindole-1,3(2H)-dione)
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Ethylene bis(tetrabromophthalimide)
- Molecular formula): C18H4Br8N2O4
- Molecular weight: 951.472 g/mol
- Substance type: Organic
- Physical state: Solid
-Smiles:c12c(C(=O)N(C1=O)CCN1C(c3c(c(Br)c(c(c3C1=O)Br)Br)Br)=O)c(c(Br)c(c2Br)Br)Br
-InChI:1S/C18H4Br8N2O4/c19-7-3-4(8(20)12(24)11(7)23)16(30)27(15(3)29)1-2-28-17(31)5-6(18(28)32)10(22)14(26)13(25)9(5)21/h1-2H2
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Ethylene bis(tetrabromophthalimide)
- Molecular formula): C18H4Br8N2O4
- Molecular weight: 951.472 g/mol
- Substance type: Organic
- Physical state: Solid
-Smiles:c12c(C(=O)N(C1=O)CCN1C(c3c(c(Br)c(c(c3C1=O)Br)Br)Br)=O)c(c(Br)c(c2Br)Br)Br
-InChI:1S/C18H4Br8N2O4/c19-7-3-4(8(20)12(24)11(7)23)16(30)27(15(3)29)1-2-28-17(31)5-6(18(28)32)10(22)14(26)13(25)9(5)21/h1-2H2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Details on test animal
TEST ANIMALS
- Weight at study initiation: 2 – 3 kg
- Fasting period before study:
- Housing: Rabbits were housed individually in cages sized in accordance with the guide for the care and use of laboratory animals’ of the institute of laboratory resources, National research council.
- Diet (e.g. ad libitum): wayne rabbit ration, ad libitum, checked daily and added or replaced as needed.
- Water (e.g. ad libitum): fresh tap water, fit for human consumption,ad libitum.
- Acclimation period: 5 Days
ENVIRONMENTAL CONDITIONS
- Temperature (°C):20°C ± 3°C
- Humidity (%):30-70%
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light
Test system
- Vehicle:
- not specified
- Controls:
- yes
- Amount / concentration applied:
- 100mg/eye
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 1, 24, 48, and 72 hours and finally at day 7
- Number of animals or in vitro replicates:
- 6 (3/sex)
- Details on study design:
- - Area of exposure: the conjunctival sac of right eye of each rabbit.
SCORING SYSTEM: according to Draize method.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 110
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Post-exposure positive responses occurred in all six rabbits at 1 hour, 2 rabbits at 24 hours, and none from 48 hours until the end of the study. Only the conjunctivae were affected. All observed effects were cleared upto 7 days.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material Ethylenebis(tetrabromophthalimide) (CAS No: 32588-76-4) was considered to be not irritating to the eyes of albino New Zealand rabbits over a 7 days observation period .
- Executive summary:
An eye irritation study of Ethylenebis(tetrabromophthalimide) (CAS No: 32588-76-4) was conducted on six (3/sex) albino New Zealand rabbits to determine the degree of irritation produced by the test substance .
About 100mg of Ethylenebis(tetrabromophthalimide) was installed into theconjunctival sac of right eye of each rabbit.24 hours prior to the application of the test material, the eyes of the rabbits were examined using 2% sodium fluorescein stain. Animals showing preexisting corneal injury were eliminated from the study. The left untreated eye served as control.
The animals were observed for ocular lesions according to Draize scoring system at 1, 24, 48, and 72 hours and finally at day 7, when the study was terminated.
Post-exposure positive responses occurred in all six rabbits at 1 hour, 2 rabbits at 24 hours, and none from 48 hours until the end of the study. Only the conjunctivae were affected.
Ethylenebis(tetrabromophthalimide) received a Draize score of 3.0 at 1 hour, 0.3 at 72 hours and 0.0 at 7 days after exposure (maximum score =110).
Since all the observed ocular lesions were cleared during 7 days post exposure period, Ethylenebis(tetrabromophthalimide) (CAS No: 32588-76-4)was considered to be not irritating to the eyes of albino New Zealand rabbit.
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