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EC number: 219-524-8 | CAS number: 2454-35-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-11-29 to 1999-12-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- (17 July, 1992)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- (1992)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Version / remarks:
- (June 1996)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- m-acetylphenyl acetate
- EC Number:
- 219-524-8
- EC Name:
- m-acetylphenyl acetate
- Cas Number:
- 2454-35-5
- Molecular formula:
- C10H10O3
- IUPAC Name:
- 3-acetylphenyl acetate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): 3-Acetoxyacetophenon ( synonymous to 3-Acetoxyacetophenon lose Ware )
- Physical state: solid
- Analytical purity: 99.0 %
- Purity test date: October 19 , 1999
- Lot/batch No.: 489
- Storage condition of test material: room temperature , light protection
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, D-88353 Kißlegg
- Weight at study initiation: 2.1 - 2.4 kg
- Housing: Individually housed in ABS-plastic rabbit cages, floor 4200 cm²
- Diet: Free access to Altromin 2123 maintenance diet for rabbits, rich in crude fiber, totally-pathogen-free-TPF
- Water: Free access to tap water (drinking water, municipal residue control, microbiol. controlled periodically)
- Acclimation period: adequate
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +/- 3
- Humidity (%): 55 +/- 10 %
- Air changes (per hr): at least 10
- Photoperiod (hrs dark / hrs light): 12 : 12, light 6.30 - 18.30
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Remarks:
- Approximately 24h before the test, fur was removed from the dorsal area of the tunk.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 g to each site - Duration of treatment / exposure:
- 4 h
- Observation period:
- examined for signs of erythma and oedema at 1, 24, 48 and 72 h after patch removal
- Number of animals:
- 3 female
- Details on study design:
- TEST SITE
- Area of exposure: approx. 6 cm², dorsal skin of the rabbit
- Type of wrap: gauze patch, non-irritating tape
REMOVAL OF TEST SUBSTANCE
- Washing: residual test item removed by using water
- Time after start of exposure: 4 h (end of exposure)
TEST SITE
- Area of exposure: approx. 6 cm², dorsal skin of the rabbit
- Type of wrap: gauze patch, non-irritating tape
REMOVAL OF TEST SUBSTANCE
- Washing: residual test item removed by using water
- Time after start of exposure: 4 h (end of exposure)
OBSERVATION TIME POINTS
1, 24, 48 and 72 h after patch removal
TEST SITE
- Area of exposure: approx. 6 cm², dorsal skin of the rabbit
- Type of wrap: gauze patch, non-irritating tape
REMOVAL OF TEST SUBSTANCE
- Washing: residual test item removed by using water
- Time after start of exposure: 4 h (end of exposure)
TEST SITE
- Area of exposure: approx. 6 cm², dorsal skin of the rabbit
- Type of wrap: gauze patch, non-irritating tape
REMOVAL OF TEST SUBSTANCE
- Washing: residual test item removed by using water
- Time after start of exposure: 4 h (end of exposure)
OBSERVATION TIME POINTS
1, 24, 48 and 72 h after patch removal
SCORING SYSTEM:
- Method of calculation: according to guideline OECD 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: all animals
- Time point:
- other: 1, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: all animals
- Time point:
- other: 1, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The test item showed no irritant effects on the intact skin after a contact time of 4 hours.
- Other effects:
- no
Any other information on results incl. tables
|
1 hour |
24 hours |
48 hours |
72 hours |
||||
Animal No. |
Erythema |
Oedema |
Erythema |
Oedema |
Erythema |
Oedema |
Erythema |
Oedema |
285 |
|
|
|
|
|
|
|
|
Test Item |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Control |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
288 |
|
|
|
|
|
|
|
|
Test Item |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Control |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
290 |
|
|
|
|
|
|
|
|
Test Item |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Control |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Irritation of the test item to the test animals: 0: no erythema/no oedema
Applicant's summary and conclusion
- Interpretation of results:
- other: "not irritating" according CLP
- Conclusions:
- Considering the reported data of this irritation study it can be stated that the test item 3-Acetoxyacetophenon (synonymous to 3-Acetoxyacetophenon lose Ware) showed no irritant/corrosive effects.
- Executive summary:
In this irritation study the test item 3-Acetoxyacetophenon was applied to one site of the closely clipped backs of 3 rabbits (strain NZW) at a dose of 0.5 g per application site. The untreated other side served as control.
The application site was covered with a semi-occulsive bandage for a 4 hour - contact time.
Observations were recorded and compared to the control sites, 1 h, 24 h, 48 h and 72 hours after removal of the dressing.
The test item 3-Acetoxyacetophenon showed no irritant affects on the intact skin after a contact time of 4 hours.
No other clinical signs of toxicity were found.
Considering the reported data of this irritation study it can be stated that the test item 3-Acetoxyacetophenon showed no irritant/corrosive effects.
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