Registration Dossier
Registration Dossier
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EC number: 272-842-9 | CAS number: 68917-63-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 August - 25 September 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Version / remarks:
- OET
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Terpenes and Terpenoids, sinpine
- EC Number:
- 272-842-9
- EC Name:
- Terpenes and Terpenoids, sinpine
- Cas Number:
- 68917-63-5
- IUPAC Name:
- Reaction mass of 1-methyl-4-(propan-2-ylidene)cyclohex-1-ene and 1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene and 2,6,6-trimethylbicyclo[7.1.1]hept-2-ene and 1-isopropyl-4-methylcyclohexa-1,4-diene
- Test material form:
- not specified
1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- other: ethanol
- Controls:
- yes
- Amount / concentration applied:
- 3, 10, 30 and 100%
- Duration of treatment / exposure:
- single application of 0.025mL and repeated applications of 0.1mL during 3 weeks
- Observation period:
- 24h for the single application and 21 days for the repeated application
- Number of animals:
- 6 to 8 per group
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 14 d
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 21 d
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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