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EC number: 635-476-4 | CAS number: 88349-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Three acute fish toxicity studies have been conducted, the results are presented below:
The first study determined the acute toxicity of CGA 153433 T (cloquintocet-acid) to rainbow trout (Oncorhynchus mykiss, formerly known as Salmo gairdneri). The study was carried out according to OECD guideline 203 (1984). The fish were exposed to the CGA 153433 T for 96 hours under static conditions. Nominal concentrations were 0 (control), 10, 18, 32, 58 and 100 mg/L, the corresponding mean measured concentrations were 0, 10.1, 17.65, 31.75, 56.45 and 99.3 mg/L, respectively. As the measured concentrations were within 20% of the nominal concentrations the results of the study are expressed in terms of nominal exposure.
The 96 hour LC50 was calculated to be 89.7 mg/ with 95% confidence intervals of 74.5 to 113 mg/L. The corresponding no-observed effect concentration was 18 mg/L.
The second study determined the acute toxicity of CGA 153433 T (cloquintocet-acid) to common carp. The study was carried out according to OECD guideline 203 (1984). The fish were exposed to the CGA 153433 T ofor 96 hours under static conditions. Nominal concentrations were 0 (control), 10, 18, 32, 58 and 100 mg/L, the corresponding mean measured concentrations were 0, 10.2, 18.85, 28.75, 58.55 and 97.75 mg/L, respectively. As the measured concentrations were within 20% of the nominal concentrations the results of the study are expressed in terms of nominal exposure.
The 96 hour LC50 was calculated to be 90 mg/L with 95% confidence intervals of 74 to 113 mg/L. The corresponding no-observed effect concentration was 58 mg/L.
The third study determined the acute toxicity of XDE-558 (cloquintocet-acid) to sheepshead minnow (Cyprinodon variegatus), a salt-water species. The study was carried out according to OECD guideline 203 (1984) and OPPTS 850.1075. The fish were exposed to XDE-558 for 96 hours under semi-static conditions, with test medium renewal after 48 hours. Nominal concentrations were 0 (control) and 120 mg/L, the corresponding mean measured concentrations were 0 and 122 mg/L, respectively. As the measured concentrations were within 20% of the nominal concentrations the results of the study are expressed in terms of nominal exposure.
The 96 hour LC50 was observed to be >120 mg/L, the corresponding no-observed effect concentration was 120 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 89.7 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 120 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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