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Diss Factsheets
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EC number: 219-845-3 | CAS number: 2550-11-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 8, 1986 to April 22, 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- pre-dates GLP
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- 4,7-dimethyloct-6-en-3-one
- EC Number:
- 219-845-3
- EC Name:
- 4,7-dimethyloct-6-en-3-one
- Cas Number:
- 2550-11-0
- Molecular formula:
- C10H18O
- IUPAC Name:
- 4,7-dimethyloct-6-en-3-one
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Batch: 117486
Aspect: slightly yellow liquid
Purity: 98.4%
Test animals
- Species:
- rat
- Strain:
- other: Füllinsdorf Albino
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Three female rats were dosed at 5 ml/kg each.
- No. of animals per sex per dose:
- 3 Females only (in both control and test groups)
- Control animals:
- yes
- Details on study design:
- Observations:
Symptoms: Twice at day of treatment and then daily for the nature, onset, and duration of all cross or visible toxic or pharmacological effects as well as rate and time of death (see table 1 of study report).
Body weight: Individual body weights were recorded on the day of treatment, 7th and 14th day of observation period.
Evaluations: Lethal doses (see Table 3 of study report) were estimated from parameters given in Table 2 without use of a statistical model. Means of body weights (see Table 4 of study report) were calculated by a PDP 11/24 computer.
The animals are observed for signs of toxicity for 14 days after intubation. The results and details of observations after treatment are summarised in table 2 of the study report. Animals were deprived of food overnight before treatment. After treatment animals were fed a commercial pelleted diet and water ad lib, and survivors are weighed before killing for post-mortem examination at the end of the two week observation period.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 mL/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality occurred
- Clinical signs:
- other: no changes observed
- Gross pathology:
- no findings observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The approximate oral acute LD50 value of Dimethyl Octenone in female rats observed over a period of 14 days was estimated to be greater than 5 ml/kg body weight.
- Executive summary:
The approximate oral acute LD50 value of Dimethyl Octenone in female rats observed over a period of 14 days was estimated to be greater than 5 ml/kg body weight.
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