Registration Dossier
Registration Dossier
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EC number: 944-802-7 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 25 °C
- pH:
- ca. 7
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 25 °C
- pH:
- 2.5
- Conclusions:
- In both experiments carried out at neutral pH and ph 2.5 no test substance peak could be observed in the chromatogram of the test substance solution. Under the same analytical conditions the retention time o f 2,4 -DDT (log POW = 6.5) was 24.5 minutes. It was assumed that the test substance elutes after the reference substance 2,4 -DDT. It is concluded that th log POW is > 6.5 at neutral pH as well as at ph 2.5.
- Executive summary:
The log POW was determined for the substance according to OECD guideline 117. The HPLC method was used, 2,4 -DDT was used as the reference substance. In both experiments carried out at neutral pH and ph 2.5 no test substance peak could be observed in the chromatogram of the test substance solution. Under the same analytical conditions the retention time o f 2,4 -DDT (log POW = 6.5) was 24.5 minutes. It was assumed that the test substance elutes after the reference substance 2,4 -DDT.
In order to show that the test substance can be passed through the HPLC column, mobile phase 3 (methanol) was used. One large test substance peak at a retention time of 2.89 minutes and several small peaks were observed in the chromatogram of the test solution.
It is concluded that the log POW is > 6.5 at neutral pH as well as at ph 2.5.
Reference
In both experiments carried out at neutral pH and ph 2.5 no test substance peak could be observed in the chromatogram of the test substance solution. Under the same analytical conditions the retention time o f 2,4 -DDT (log POW = 6.5) was 24.5 minutes. It was assumed that the test substance elutes after the reference substance 2,4 -DDT.
In order to show that the test substance can be passed through the HPLC column, mobile phase 3 (methanol) was used. One large test substance peak at a retention time of 2.89 minutes and several small peaks were observed in the chromatogram of the test solution.
Description of key information
The log POW was experimentally determined according to OECD guideline 117 using the HPLC method. A value of > 6.5 was obtained.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.5
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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