Registration Dossier
Registration Dossier
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EC number: 218-737-3 | CAS number: 2222-33-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from study reprot
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity of 5,12-dihydroquino[2,3-b]acridine-7,14-dione in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- EC Number:
- 213-879-2
- EC Name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- Cas Number:
- 1047-16-1
- Molecular formula:
- C20H12N2O2
- IUPAC Name:
- 5,12-dihydroquino[2,3-b]acridine-7,14-dione
- Test material form:
- solid
- Details on test material:
- Name of the test chemical:5,12-dihydroquino[2,3-b]acridine-7,14-dione
Molecular Formula:C20H12N2O2
Molecular Weight: 312.327 g/mole
Substance Type: Organic
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical:5,12-dihydroquino[2,3-b]acridine-7,14-dione
Molecular Formula:C20H12N2O2
Molecular Weight: 312.327 g/mole
Substance Type: Organic
Physical State: Solid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 3200 mg/kg/day
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 3 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No effect on survival of treated rats were observed at 3200 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be > 3200 mg/kg/day when rats were treated with 5,12-dihydroquino[2,3-b]acridine-7,14-dione orally.
- Executive summary:
In acute oral toxicity study, rats were treated with 5,12-dihydroquino[2,3-b]acridine-7,14-dione in the concentration of 3200 mg/kg/day orally.No effect on survival of treated rats were observed at 3200 mg/kg bw. Therefore, LD50 was considered to be> 3200 mg/kg/day when rats were treated with 5,12-dihydroquino[2,3-b]acridine-7,14-dione orally.
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