Registration Dossier
Registration Dossier
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EC number: 246-613-9 | CAS number: 25103-09-7
Endpoint summary
Administrative data
Description of key information
An acute toxicity study has been conducted with 2-ethylhexyl thioglycolate, a structural analogue of IOTG, by the oral route (Schmidt et al, 1974). The acute oral toxicity value indicate moderate toxicity, with LD50 value in rats of 303 – 334 mg/kg bw. Acute dermal and inhalation toxicity of IOTG is low, with 7-hour inhalation LC0 values in rats higher than 0.36 mg/L air (vapours generated at room temperature) or > 14.3 mg/L air (vapours generated at 135°C) (Rampy, 1973) and a dermal LD0 in rats greater than 2000 mg/kg bw (Clouzeau, 1993).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 303 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- discriminating conc.
- Value:
- 360 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
According to REGULATION (EC) No 1272/2008 of 16 December 2008 and the available acute toxicity data, iso-octyl mercaptoacetate is classified:
- Acute oral toxicity: Toxic, category 4 (based on 2 -EHTG data)
- Acute inhalation toxicity: not classified
- Acute dermal toxicity: not classfied
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