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EC number: 238-744-5 | CAS number: 14694-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute oral LD50 for chlorotris-(triphenylphosphine)-rhodium(I) was established to be above 5000 mg/kg bw in rats (Mayr, 1988a).
No relevant acute dermal or inhalation toxicity data were identified, or are required at this tonnage.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 22-May 6 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was carried out in accordance with the relevant OECD guideline for 1988, the year in which it was performed, and was GLP compliant.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Wistar Bor: WISW (SPFTNO)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Winkelmann Versuchstierzucht GmbH & Co. KG., D-4799 Borchen
- Age at study initiation: Males, 9 weeks; Females, 10 weeks
- Weight at study initiation: Males, 180-226 g; Females, 147-175 g
- Fasting period before study:16 hrs before treatment
- Housing: Macrolon cages, type II
- Diet (e.g. ad libitum): standard diet ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5-21.5ºC
- Humidity (%): 35-65%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 06:00-18:00 hrs artificial lighting; 18:00-06:00 hrs natural light-dark-rhythm
IN-LIFE DATES: From: To:- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous Tylose suspension (1%)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle:250 mg/ml
- Amount of vehicle (if gavage): 20 ml/kg bw
- Justification for choice of vehicle: test substance not soluble in water
- Lot/batch no. (if required): no data (Tylose supplied by Hoeschst AG, D-6000 Frankfurt)
- Purity: no data
MAXIMUM DOSE VOLUME APPLIED: 20 ml/kg bw
DOSAGE PREPARATION (if unusual):
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 rats/sex/dose
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were continuously observed for first 4-8 hrs after administration and then twice daily. Bodyweights were recorded at the beginning and at 7 and 14 days after administration of test substance.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight- Statistics:
- No statistical analysis was performed.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No deaths occurred during the 14-day observation period after 5 male and 5 female rats were treated with 5000 mg/kg bw test substance.
- Clinical signs:
- No systemic toxic effects were observed.
- Body weight:
- Body weights for the treated animals were reported for days 0, 7 and 14 of the study. Both male and female animals showed increased bodyweights at day 7 and again at day 14. However, bodyweight data for vehicle control animals or historical laboratory data are not provided. The study authors do not comment on bodyweight increases.
- Gross pathology:
- No abnormalities were detected on gross necropsy at the end of the 14-day observation period. Macroscopic examination included external appearance, body orifices, body cavities (thoracic and abdominal) and their contents).
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 for chlorotris-(triphenylphosphine)-rhodium(I) was established to be above 5000 mg/kg bw in rats.
- Executive summary:
The acute oral toxicity of chlorotris-(triphenylphosphine)-rhodium(I) was investigated in an OECD Test Guideline 401 study, conducted according to GLP. Test substance was administered by oral stomach tube to Wistar Bor rats (5/sex) at a limit dose of 5000 mg/kg bw (in aqueous Tylose suspension). Animals were observed daily and weighed weekly. No mortality was observed over the 14-day observation period and no abnormalities were seen at macroscopic post mortem examination. The acute oral LD50 value for chlorotris-(triphenylphosphine)-rhodium(I) in rats was therefore established to be above 5000 mg/kg bw.
Based on the results of this study, no classification is required for acute oral toxicity according to EU CLP criteria (EC 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No relevant human acute toxicity data were identified.
The acute oral toxicity of chlorotris-(triphenylphosphine)-rhodium(I) was investigated in an OECD Test Guideline 401 study, conducted according to GLP. Test substance was administered by oral stomach tube to Wistar Bor rats (5/sex) at a limit dose of 5000 mg/kg bw (in aqueous Tylose suspension). Animals were observed daily and weighed weekly. No mortality was observed over the 14-day observation period and no abnormalities were seen at macroscopic post mortem examination. The acute oral LD50 value for chlorotris-(triphenylphosphine)-rhodium(I) in rats was therefore established to be above 5000 mg/kg bw (Mayr, 1988a).
No acute dermal or inhalation toxicity data were identified, or are required at this tonnage (1-10 tpa).
Justification for selection of acute toxicity – oral endpoint
OECD guideline study, and the only acute oral toxicity study available.
Justification for classification or non-classification
Based on the results of the available and reliable acute oral rat study, tris(triphenylphosphine) rhodium(I) chloride does not require classification for acute oral toxicity according to EU CLP criteria (EC 1272/2008).
No clear evidence of specific target organ toxicity was noted. As such, classification for STOT-SE is not considered appropriate.
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