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EC number: 425-320-1 | CAS number: 690-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Gene mutation (Bacterial Reverse Mutation Assay/Ames test):
The substance 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) was tested in one in vitro gene mutation study in bacteria (Bacterial Reverse Mutation Assay/Ames Test). In the key study (OECD 471 and 472/GLP), bacterial strains (Salmonella typhimurium TA100, TA1535, TA98, TA97 and Escherichia coli/ WP2uvrA(pKM101)) were exposed to the 100% of the substance and additional lower concentrations of 0% (air), 20%, 40%, 60%, 70% and 80% in the presence and absence of mammalian metabolic activation (Aroclor induced rat-liver S9) in duplicate. The substance was negative in the presence and absence of metabolic activation in the Bacterial Reverse Mutation Assay/Ames test.
Chromosome aberration (in vitro mammalian cell cytogenicity):
The substance 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) was tested in one in vitro mammalian cytogenicity (Chromosome aberration) study. In the mammalian cell cytogenetic key study (Chromosome aberration; OECD 473/GLP), human lymphocytes were exposed to the substance in dry compressed air at concentrations of 0 – 100% (2 assays with varying increasing concentrations) with (3 hrs) and without (3 hrs) metabolic activation (rat liver induced with Aroclor 1254). The substance was negative in the presence and absence of metabolic activation in the in vitro mammalian cell cytogenicity (Chromosome aberration) assay.
Chromosome aberration (in vivo micronucleus assay):
The substance 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) was tested in an in vivo micronucleus assay (Chromosome aberration) study. In the micronucleus assay (OECD 474/GLP), the mice were exposed to the substance at doses of 5000 ppm, 20000 ppm and 50000 ppm. The results of this study did not give an indication on the potential of the substance to induce chromosomal aberrations in vivo.
Justification for selection of genetic toxicity endpoint
No key study was selected as all three studies were negative.
Short description of key information:
In vitro:
Gene mutation (Bacterial Reverse Mutation Assay/Ames test): the substance 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) does not induce mutagenicity using S. typhimurium TA100 TA1535 TA98 TA97 and Escherichia coli/ WP2uvrA(pKM101) in the presence or absence of Aroclor 1254 rat liver-induced S9 metabolic activation (OECD 471/472, GLP);
Chromosome aberration (in vitro mammalian cell cytogenicity): the substance 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) does not induce chromosome aberrations in Human lymphocytes in the presence or absence of Aroclor 1254 rat liver-induced S9 metabolic activation (OECD 473, GLP);
In vivo:
Micronucleus assay: the substance 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) does not induce chromosome aberrations in vivo after administration to Crl:CD-1(ICR)BR mice (OECD 474, GLP).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available information in the dossier, the substance 1,1,1,3,3,3-Hexafluoropropane (CAS No. 690-39-1) does not need to be classified for germ cell mutagenicity when the criteria outlined in Annex I of 1272/2008/EC are applied
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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