[1R-(1α,2β,4β,6α)]-2,2,7-trimethyl-3-oxatricyclo[4.1.1.02,4]octane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

other information

Study period:

No data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only a very brief report in a secondary source is available on the unspecified isomer. Primary Russian publication (Volkova et al. 1998) could not be obtained

Data source

Reference

Reference 1

Reference Type:

publication

Title:

[Unknown]

Author:

Volkova NV et al.

Year:

1998

Bibliographic source:

Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia (Hazardous substances. Nature products), 285

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

2003

Materials and methods

Principles of method if other than guideline:

No data on methodology given in secondary source

GLP compliance:

not specified

Test type:

other: no data

Test material

Test material information

Constituent 1

Reference substance name:

alpha pinene epoxide (unspecified isomer)

IUPAC Name:

alpha pinene epoxide (unspecified isomer)

Constituent 2

Reference substance name:

2,7,7-trimethyl-3-oxatricyclo[4.1.1.02,4]octane

EC Number:

216-869-6

EC Name:

2,7,7-trimethyl-3-oxatricyclo[4.1.1.02,4]octane

Cas Number:

1686-14-2

Molecular formula:

C10H16O

IUPAC Name:

2,7,7-trimethyl-3-oxatricyclo[4.1.1.0~2,4~]octane

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report): pinane, 2,3-epoxy-- Molecular formula (if other than submission substance): C10-H16-O- Molecular weight (if other than submission substance): 152.235- Smiles notation (if other than submission substance): C1([C@@H]2[C@@]3(O[C@@H]3C[C@@H]1C2)C)(C)C- InChl (if other than submission substance): 1S/C10H16O/c1-9(2)6-4-7(9)10(3)8(5-6)11-10/h6-8H,4-5H2,1-3H3 - Structural formula attached as image file (if other than submission substance): see Fig. 1- Substance type: no data in citing source- Physical state: no data in citing source- Analytical purity: no data in citing source- Impurities (identity and concentrations): no data in citing source- Composition of test material, percentage of components: no data in citing source- Isomers composition: no data in citing source- Purity test date: no data in citing source- Lot/batch No.: no data in citing source- Expiration date of the lot/batch: no data in citing source- Stability under test conditions: no data in citing source- Storage condition of test material: no data in citing source

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Doses:

No data in citing source

No. of animals per sex per dose:

No data in citing source

Control animals:

not specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 2.4 mL/kg bw

Based on:

not specified

Remarks on result:

other: No exposure duration or confidence intervals given.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated informationCriteria used for interpretation of results: EU

Conclusions:

A secondary source (RTECS) provides limited details of an acute oral [presumably gavage] toxicity study conducted on rats given pinene alpha epoxide (unspecified isomer). The reported oral LD50 was 2.4 ml/kg bw [about 2.4 g/kg bw].

Executive summary:

A secondary source (RTECS) provides limited details of an acute oral toxicity study conducted on rats given pinene alpha epoxide (unspecified isomer) [presumably by gavage]. [The original Russian publication could not be obtained.] The reported oral LD50 was 2.4 ml/kg bw [about 2.4 g/kg bw].

According to the EU CLP and DSD regulations, this would not require classification for acute oral toxicity.