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Diss Factsheets
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EC number: 267-510-5 | CAS number: 67874-81-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute
oral toxicity: similar to OECD TG 401: LD50 > 5000 mg/kg bw
Acute dermal toxicity: similar to OECD TG 402: LD50 > 5000 mg/kg bw
Acute inhalation toxicity: route to route extrapolation from oral: > 13000 mg/m3.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Clinical signs:
- No clinical signs observed
- Interpretation of results:
- other: not orally acutely toxic
- Remarks:
- EU CLP criteria
- Conclusions:
- The acute oral toxicity test showed an LD50 of > 5000 mg/kg bw
- Executive summary:
In a pre-GLP acute toxicity study similar to OECD 401, 10 rats were orally exposed to 5000 mg/kg bw test substance. All animals survived the 14 -day observation period. Under the conditions of the test the acute oral LD50 was determined to be >5000 mg/kg bw in rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study is considered to be a reliability 2 study since it predates GLP but is similar to OECD TG 401.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Other findings:
- Skin irritation: Slight redness 5 out of 10; Moderate redness 5 out of 10; Slight edema 4 out of 10; Moderate edema 6 out of 10
- Interpretation of results:
- other: not dermally acutely toxic
- Remarks:
- EU CLP criteria
- Conclusions:
- The acute dermal toxicity test showed an LD50 > 5000 mg/kg bw
- Executive summary:
In a pre-GLP acute toxicity study similar to OECD 402, 10 rabbits were dermally exposed to 5000 mg/kg bw test substance. All animals survived the 14 -day observation period. Under the conditions of the test the dermal LD50 was determined to be >5000 mg/kg bw in rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study is considered to be a reliability 2 study since it predates GLP but is similar to OECD TG 402.
Additional information
Acute oral toxicity:
In a pre-GLP acute toxicity study similar to OECD 401, 10 rats were orally exposed to 5000 mg/kg bw test substance. All animals survived the 14 -day observation period. Under the conditions of the test the acute oral LD50 was determined to be >5000 mg/kg bw in rats.
Acute dermal toxicity:
In a pre-GLP acute toxicity study similar to OECD 402, 10 rabbits were dermally exposed to 5000 mg/kg bw test substance. All animals survived the 14 -day observation period. Under the conditions of the test the dermal LD50 was determined to be >5000 mg/kg bw in rabbits.
Acute inhalation toxicity:
The acute inhalation toxicity for the substance can be derived using data on the acute oral toxicity using the following methodology:CLP guidance (2015 3.1.6.1.8. Example 8, page 268):using the extrapolation formula 1 mg/kg bw = 0.0052 mg/l/4h.
The LD50 of the substance for acute oral toxicity is > 5000 mg/kg bw. This 5000 mg/kg bw can be converted to > 26 mg/l = 26 gram/m3. Taking into account the inhalation absorption as 100% and oral absorption 50%, the acute inhalation toxicity would become =>13000 mg/kg bw.
The saturated vapour pressure of the substance is: 48.5 mg/m3 (MW*VapPres/ (8.3*293). This means that the acute inhalation LC50 > 13000 mg/m3 cannot be reached because it exceeds the saturated vapour pressure by more than a factor of 200 (268).Justification for classification or non-classification
Based on the experimental results of the acute oral and dermal toxicity tests and the derived value for inhalation toxicity the substance does not have to be classified for acute toxicity in accordance with CLP, Regulation (EC) No. 1272/2008 and its amendments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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