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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
5-[ethyl(2-hydroxyethyl)amino]pentan-2-one
EC Number:
277-901-2
EC Name:
5-[ethyl(2-hydroxyethyl)amino]pentan-2-one
Cas Number:
74509-79-8
Molecular formula:
C9H19NO2
IUPAC Name:
5-[ethyl(2-hydroxyethyl)amino]pentan-2-one
Test material form:
liquid

Sampling and analysis

Analytical monitoring:
yes

Test organisms

Test organisms (species):
Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Details on test organisms:
The algae were supplied by the „Sammlung von Algenkulturen, Albrecht-von-Haller-Institut für Pflanze nwissenschaften, Universität Göttingen", 37073 Göttingen, Germany.

Test conditions

Hardness:
0.24 mmol/L (= 24 mg/L) as CaCO3
Test temperature:
Water temperature was 23 to 24 °C
pH:
7.9 to 8.1 at test start.
8.0 to 10.2 at test end.
Nominal and measured concentrations:
100, 32, 10, 3.2, and 1.0 mg test item/L and a control/

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
3.2 mg/L
Nominal / measured:
nominal
Basis for effect:
cell number
Key result
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
3.2 mg/L
Nominal / measured:
nominal
Basis for effect:
growth rate
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
42.8 mg/L
Nominal / measured:
nominal
Basis for effect:
growth rate
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
19.1 mg/L
Nominal / measured:
nominal
Basis for effect:
cell number

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The influence of HYDROXY NOVOL KETONE on the growth of the freshwater green algae Pseudokirchneriella subcapitata was assessed in a static concentration-response test. The 72-hour EyC50 was calculated to be 19.1 mg test item/L and the 72-hour ErC50 value was calculated to be 42.8 mg test item/L. The 72-hour NOEyC was determined to be 3.2 mg test item/L and the associated 72-hour LOEyC was 10 mg test item/L. The 72-hour NOErC was determined to be 3.2 mg test item/L and the associated 72-hour LOErC was 10 mg test item/L.