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EC number: 203-939-6 | CAS number: 112-14-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acetate C-8 is likely to be non hazardous by oral and dermal route of exposure in rats and rabbits.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity test was conducted in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3000 mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % morality was observed
- Mortality:
- 50 % morality was observed in traded rats at 3000 mg/kg
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- practically nontoxic
- Conclusions:
- LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.
- Executive summary:
In a acute oral toxicity study, rats were treated wtih Acetate C-8 in the contrition of 3000 mg/kg orally. 50 % morality was observed in traded rats at 3000 mg/kg. Therefore, LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from peer reviewed journal
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer-reviewed jouranl
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Acute dermal toxicity test of Acetate C-8 in rabbits.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No morality was observed
- Mortality:
- No morality was observed in traded rabbits at 5000 mg/kg
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- practically nontoxic
- Conclusions:
- LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.
- Executive summary:
In a acute dermal toxicity study, rabbits were treated with Acetate C-8 in the contrition of 5000 mg/kg dermally. No morality was observed in traded rabbits at 5000 mg/kg. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from peer reviewed journal
Additional information
Acute oral toxicity:
Based on the data available for target Acetate C-8 (CAS no 112-14-1) is summarized below
In study conducted by Baret al(1974), acute oral toxicity was evaluated in rats by using Acetate C-8 in the contrition of 3000 mg/kg orally. 50 % morality was observed in traded rats at 3000 mg/kg. Therefore, LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.
In a study given by Daughtreyet al(1989), acute oral toxicity was evaluated rats by using Octyl Acetate in the concentration of 5000 mg/kg bw orally. 50% mortality was observed in treated rats at 5000 mg/kg bw. Therefore, LD50 was considered to be approximately 5000 mg/kg bw when rat were treated with Octyl Acetate orally.
Based on the prediction done by using QSAR Toolbox 3.4. (2016), acute oral toxicity was estimated in albino female rats by using Octyl Acetate orally. 50 % mortality was observed at 4263.5 mg/kg bw in treated female rats. Therefore, estimated LD50 was considered to be 4263.5 mg/kg bw when albino female rats were treated with Octyl Acetate orally.
Thus, based on the available data for target Acetate C-8 (CAS no 112-14-1) is likely to be non hazardous by oral route of exposure in rats.
Acute dermal toxicity:
Based on the data available for target Acetate C-8 (CAS no 112-14-1) is summarized below
In study conducted by Moreno,et al(1974), acute dermal toxicity was evaluated in rabbits by using Acetate C-8 in the contrition of 5000 mg/kg dermally. No morality was observed in traded rabbits at 5000 mg/kg. Therefore, LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.
In a study given by Daughtreyet al(1989), acute dermal toxicity was evaluated in rabbits by using Octyl Acetate in the concentration of 3000 mg/kg bw dermally. No mortality was observed in treated rabbits at 3000 mg/kg bw. Therefore, LD50 was considered to be > 3000 mg/kg bw when rabbits were treated with Octyl Acetate dermally.
Based on the prediction done by using QSAR Toolbox 3.4. (2016), acute dermal toxicity was estimated in rabbits by using Octyl Acetate dermally. 50 % mortality was observed at 4655 mg/kg bw in treated rabbits. Therefore, estimated LD50 was considered to be 4655mg/kg bw when rabbits were treated with Octyl Acetate dermally.
Thus, based on the available data for target Acetate C-8 (CAS no 112-14-1) is likely to be non hazardous by dermal route of exposure in rabbits.
Justification for selection of acute toxicity – oral endpoint
LD50 was considered to be 3000 mg/kg when rat were treated with Acetate C-8 orally.
Justification for selection of acute toxicity – dermal endpoint
LD50 was considered to be > 5000 mg/kg when rabbits were treated with Acetate C-8 dermally.
Justification for classification or non-classification
Based on the available data for target Acetate C-8 (CAS no 112-14-1) is likely to be non hazardous by oral and dermal route of exposure in rats and rabbits..
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