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Diss Factsheets
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EC number: 203-851-8 | CAS number: 111-26-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from GSBL
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Range-Finding Toxicity Data, List V
- Author:
- GSBL
- Year:
- 1 996
- Bibliographic source:
- German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety and the Environmental Ministries of all 16 Federal States of Germany
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of Hexylamine in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Hexylamine
- EC Number:
- 203-851-8
- EC Name:
- Hexylamine
- Cas Number:
- 111-26-2
- Molecular formula:
- C6H15N
- IUPAC Name:
- hexan-1-amine
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): Hexylamine
- Molecular formula (if other than submission substance): C6H15N
- Molecular weight (if other than submission substance): 101.191 g/mole
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: 90-120g
Fasting period before study: Not fasted before dosing
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE
Concentration in vehicle: 25% in water
Amount of vehicle (if gavage):between 1 -10ml
Justification for choice of vehicle: an aqueous solution of 25% Na 3,9-diethyl6-tridecanolsulfat was dissolved in water, corn oil or 1% Tergitol 7 Penetrant dissolved. - Doses:
- No data
- No. of animals per sex per dose:
- 5 male
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?): 14 days
- Statistics:
- LD50 value and range of confidence were determined by the Thompson method (Bacteriol Rev. 11, 1947, p. 115) using the tables of Weil (Biometrics 8, 1952, p 249).
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 670 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality observed in treated male rats.
- Clinical signs:
- No data
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be 670 mg/kg be when Wistar male rats were treated with hexylamine.
- Executive summary:
In a acute oral toxicity study, Wistar male rats by using Hexylamine orally by gavage and observed for 14 days. 50 % mortality was observed in treated male rats at 670 mg/kg bw. Therefore, LD50 was considered to be 670 mg/kg be when Wistar male rats were treated with hexylamine.
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