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Diss Factsheets
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EC number: 213-909-4 | CAS number: 1066-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with limited documentation and acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of the potential genotoxicity of chromium picolinate in mammalian cells in vivo and in vitro.
- Author:
- Andersson, M.A. et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45, 1097-1106
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- yes
- Remarks:
- only one sampling time
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 14639-25-9
- Cas Number:
- 14639-25-9
- IUPAC Name:
- 14639-25-9
- Details on test material:
- - Name of test material (as cited in study report): chromium picolinate
- Analytical purity: analytical quality
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: CBA/Ca
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Scanbur BK
- Age at study initiation: 7 - 8 weeks
- Weight at study initiation: ca. 20 g
- Diet (e.g. ad libitum): standardized rodent pellet diet, batch 3386
- Water (e.g. ad libitum): tap water
- Acclimation period: at least 7 days
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- phosphate buffered saline (PBS)
- Duration of treatment / exposure:
- single injection
- Frequency of treatment:
- once
- Post exposure period:
- 42 h sampling time
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.75, 1.5 and 3 mg/kg bw
Basis:
other: administered dose
- No. of animals per sex per dose:
- 3
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- colchicine
- Justification for choice of positive control(s): appropriate positive control for the micronucleus assay when using mice as test species (Cammerer et al. 2007, Mutagenesis 22, 129-134)
- Route of administration: intraperitoneal
- Doses / concentrations: 1 mg/kg
Examinations
- Tissues and cell types examined:
- peripheral blood erythrocytes (polychromatic)
- Details of tissue and slide preparation:
- CRITERIA FOR DOSE SELECTION: Because of the poor solubility of the test substance, 3 mg/kg was the highest dose possible to administer.
METHOD OF ANALYSIS: flow cytometer-based micronucleus assay; staining of the cells with Hoechst 33342 and thiazole orange
OTHER:
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
Any other information on results incl. tables
Treatment |
Dose [mg/kg] |
Frequency of PCE with MN [‰] (mean ± SEM) |
Frequency of PCE [%] |
Control |
0 |
1.00 ± 0.05 |
1.9 ± 0.4 |
Cr picolinate |
0.75 |
0.95 ± 0.08 |
2.4 ± 0.4 |
1.5 |
0.94 ± 0.04 |
2.1 ± 0.3 |
|
3.0 |
1.08 ± 0.13 |
2.2 ± 0.3 |
|
Colchicine |
1.0 |
3.78 ± 0.46 |
1.0 ± 0.4 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.