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Diss Factsheets
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EC number: 268-655-7 | CAS number: 68132-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Ministry of Trade and Industry Test Protocol for Testing of New Chemical Substances
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 D (Bioaccumulation: Static Fish Test)
- GLP compliance:
- no
- Radiolabelling:
- no
- Details on sampling:
- Water samples from the exit to the test vessels were taken at least twice weekly throughout the test. The absorption at 620 nm and 800 nm was measured.
Carp were taken from each of the two test and control vessels at weekly intervals throughout the test, and stored in ''polythene" bags in the deep freeze until the end of the test period. Before analysis the fish were allowed to thaw and weighed. They were then dried at 105°C for 48 hours and re-weighed. Each fish was placed in a quartz/silica flask and 20 mL of "Aristar" nitric acid added. The top of the flask was covered with a watch glass, and the mixture placed on a 130°C hot plate for 24 hours . It was then filtered through a Whatman GF-B glass fibre filter and made up to 25 mL with Q.D.W. These solutions were anlysed for copper using the atomic absorption spectrometer, with deuterium lamp correction for non-atomic absorption. - Vehicle:
- not specified
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- The fish used were Mirror Carp (Cyprinus carpio) which prior to the test were acclimatised to the test conditions for a period of 7 days. The fish were randomly selected from stock fish which had all been in good health for a period of at least two weeks prior to the acclimatisation period.
- Route of exposure:
- aqueous
- Justification for method:
- aqueous exposure method used for following reason: water soluble substance with low log Kow
- Test type:
- static
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 8 wk
- Reference substance (positive control):
- no
- Details on estimation of bioconcentration:
- BASIS INFORMATION
- Measured/calculated logPow: < -6.6 - Key result
- Conc. / dose:
- 2.34 mg/L
- Temp.:
- 23.3 °C
- pH:
- 7.8
- Type:
- BCF
- Value:
- 6 L/kg
- Basis:
- whole body d.w.
- Calculation basis:
- steady state
- Key result
- Conc. / dose:
- 22.66 mg/L
- Temp.:
- 23.3
- pH:
- 7.8
- Type:
- BCF
- Value:
- 3 L/kg
- Basis:
- whole body d.w.
- Calculation basis:
- steady state
- Details on results:
- - Mortality of test organisms: no mortality observed
- Behavioural abnormalities: none
- Other biological observations: none
- Organ specific bioaccumulation:
- Bound residues forming a plateau:
- Mortality and/or behavioural abnormalities of control: none observed
- Loss of test substance during test period: average measured concentrations = 2.34 mg/L (2.5 mg/L nominal, recovery 93.6%), 22.66 mg/L (25.0 mg/L nominal, recovery 90.7%) - Validity criteria fulfilled:
- not specified
- Conclusions:
- The 8 wk-BCF in Cyprinus carpio was determined at 6 L/kg (2.34 mg/L aqueous exposure) and 3 L/kg (22.66 mg/L aqueous exposure) based on measured concentrations.
- Executive summary:
The 8 wk-BCF in Cyprinus carpio was determined at 6 L/kg (2.34 mg/L aqueous exposure) and 3 L/kg (22.66 mg/L aqueous exposure) based on measured concentrations. In neither case there was any evidence that the accumulation increased with time. No mortality or other biological or behavioural abnormalities were found. No significant risk of bioaccumulation in fish was detected.
Reference
Description of key information
The 8 wk-BCF in Cyprinus carpio were determined at 6 L/kg (2.34 mg/L aqueous exposure) and 3 L/kg (22.66 mg/L aqueous exposure) based on measured concentrations. In neither case there was any evidence that the accumulation increased with time. No mortality or other biological or behavioural abnormalities were found. No significant risk of bioaccumulation in fish was detected.
Key value for chemical safety assessment
- BCF (aquatic species):
- 6 L/kg ww
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.