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EC number: 604-351-6 | CAS number: 143390-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water: sediment simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
- Reference Type:
- other: FOCUS calculation
- Title:
- Unnamed
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: BBA Guideline part IV, 5-1
- Qualifier:
- according to guideline
- Guideline:
- EPA Subdivision N Pesticide Guideline 162-4 (Aerobic Aquatic Metabolism)
- GLP compliance:
- yes
Test material
- Reference substance name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- EC Number:
- 604-351-6
- Cas Number:
- 143390-89-0
- Molecular formula:
- C18 H19 N O4
- IUPAC Name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- Details on test material:
- - Name of test material (as cited in study report): [ring-A-14C]242009
- Lot No.: 39/149-1 and L48/92 (Z-isomer)
- Radiochemical purity: >= 95% (incl. Z-isomer 242010, which comprise ca. 10% of total radioactivity)
- Specific activity: 4.41 MBq/mg
- Locations of the label: ((E)-2-[2-(2-Methyl-[ring-U-14C]phenoxy)-methyl]phenyl-
2-(methoxyimido)acetic acid methyl ester ("ring-A-14C-labelled BAS 490 F")
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water / sediment
- Details on source and properties of surface water:
- Water/sediment System #1:
- Location: stream "Großer Graben", near D-25361 Krempe/Elmshom in a marsh area surrounded by arable land and pastures
- Temperature at time of collection: 17 °C (water)
- pH at time of collection: 7.7
- Oxygen concentration initial: 9.8 – 9.9 mg/L
- Redox potential initial: 198 mV (water)
- TOC: 50 mg/L
- Water hardness: 3.8 mmol/L
Water/sediment System #2:
- Location: stream "Ohlau", near D-24632 Lentfohrden surrounded by pastures
- Temperature at time of collection: 14 °C
- pH at time of collection: 7.8
- Oxygen concentration initial: 10.4 – 10.8 mg/L
- Redox potential initial: 253 mV
- TOC: 28 mg/L
- water hardness: 1.3 mmol/L - Details on source and properties of sediment:
- Water/sediment System #1:
- Location: stream "Großer Graben" , near D-25361 Krempe/Elmshom in a marsh area surrounded by arable land and pastures
- pH at time of collection: 7.1
- organic carbon: 3.2%
- cation exchange capacity [meq/100 g soil]: 20
- particle size:
< 0.002 mm = 18.3%
0.002-0.006 mm = 5%
0.006-0.02 mm = 10.3
0.02-0.063 mm = 29.8%
0.063-0.2 mm = 23%
0.2-0.63 mm = 11.7%
0.63-2 mm = 1.9%
Water/sediment System #2:
- Location: stream "Ohlau", near D-24632 Lentfohrden surrounded by pastures
- pH at time of collection: 6.3
- organic carbon: 0.11%
- cation exchange capacity [meq/100 g soil]: 2.5
- particle size:
< 0.002 mm = 0.7%
0.002-0.006 mm = 0.1%
0.006-0.02 mm = 0.1
0.02-0.063 mm = 0.4%
0.063-0.2 mm = 1.6%
0.2-0.63 mm = 82%
0.63-2 mm = 14.5% - Duration of test (contact time):
- 100 - 102 d
Initial test substance concentration
- Initial conc.:
- 0.17 other: mg/kg
- Based on:
- act. ingr.
- Parameter followed for biodegradation estimation:
- radiochem. meas.
- Details on study design:
- THE TEST SOLUTION
- Preparation: 10.6 mg unlabelled test substance were dissolved in 5 ml acetonitrile. 1.0 ml of this solution (2.12 mg unlabelled test substance) was added to a solution containing 12.6 MBq [14C]-test substance; at the spec. radioactivity of 4.41 MBq/mg this is equivalent to 2.87 mg of the undiluted 14C-labelled test substance. This solution was made up to 25.0 ml, in total containing 4.99 mg 14C-labelled test substance.
TEST SYSTEM
- Culturing apparatus: incubation flasks equipped with a stirrer, a trap for volatile components and a septum allowing the introduction of gas
- Aerobic and anaerobic conditions: At 20 °C in the dark the water was slowly stirred. Thus, aerobic conditions are achieved in the water, whereas a gradient in the redox potential is found in parts of the sediment.
- Intervals of abiotic measurement: Dissolved oxygen, redox potential, temperature and pH in the water are measured at each sampling date
- Details of trap for CO2 and volatile organics: containing with paraffin oil impregnated quartz wool and soda lime
- Flask preparation: containing a sediment layer of 2.5 cm and a water layer of 6 cm. Placed on an orbital stirrer at 20 °C and allowed to equilibrate for ca. 3 weeks before 14C-labled substance was applied.
- Heat-sterilization: two of the flasks, before application, three times 30 min/212 °C on three successive days
- Number of culture flasks/system: 22 (2 flasks heat sterilized)
- Total flask weight: 580 g
- Test substance application: 0.5 ml acetonitrile solution with 14C-labelled test substance were applied to the flasks
- Test substance concentration/flask: 0.10 mg (0.17 mg/kg water)
- Radioactivity/flask: 258 kBq
Reference substance
- Reference substance:
- other: free acid of BAS 490 F (denominated BF 490-1)
Results and discussion
% Degradationopen allclose all
- % Degr.:
- 8
- Parameter:
- CO2 evolution
- Sampling time:
- 100 d
- Remarks on result:
- other: System "Krempe"
- % Degr.:
- 10
- Parameter:
- CO2 evolution
- Sampling time:
- 100 d
- Remarks on result:
- other: System "Ohlau"
Half-life of parent compound / 50% disappearance time (DT50)open allclose all
- Compartment:
- entire system
- DT50:
- 1.26 d
- Type:
- other: single first order
- Remarks on result:
- other: System "Krempe"; half-life estimated by FOCUS modelling
- Compartment:
- entire system
- DT50:
- 1.36 d
- Type:
- other: single first order
- Remarks on result:
- other: System "Ohlau"; half-life estimated by FOCUS modelling
- Compartment:
- entire system
- DT50:
- 1.5 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: System "Krempe" (DT90 = 6.5 d); half-life values based on measurements
- Compartment:
- entire system
- DT50:
- 1.6 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: System "Ohlau" (DT90 = 6.6 d); half-life values based on measurements
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- corresponding acid BF 490-1 (E-isomer)
- Identifier:
- common name
- Identity:
- corresponding acid BF 490-1 (E-isomer)
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- Z-isomer of the corresponding acid BF 490-1
- Identifier:
- common name
- Identity:
- Z-isomer of the corresponding acid BF 490-1
- No.:
- #3
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- humins
- Identifier:
- common name
- Identity:
- humins
- No.:
- #4
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- humic acids
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 215-809-6]
- Identifier:
- common name
- Identity:
- humic acids
- No.:
- #5
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- fulvic acids
- Identifier:
- common name
- Identity:
- fulvic acids
- Details on transformation products:
- - Corresponding acid BF 490-1, E-isomer: rapidly formed by hydrolysis and enzymatic or microbial action (radioactivity found in this acid was after 100 days slightly below 70% in both systems
- Z-isomer of the corresponding acid BF 490-1: Radioactivity found in this acid was after 100 days approx. 7% in both systems)
- Humins, humic acids and fulvic acids: 12% radioactivity in the sediment of the system "Krempe"
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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