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Diss Factsheets
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EC number: 940-265-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-01-10 to 2005-03-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant; Guideline Study (OECD 203)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: In this semi-static test with a test medium renewal every day, fourfold samples were taken from the freshly prepared test medium and the control at the start of the test (Day 0) and at the last test medium preparation on Day 3. Additionally, fourfold samples were taken from the test medium and the control at the end of the first test medium renewal period (Day 1) and at the end of the last test rnediumrenewal (Day 4).
- Sample storage conditions before analysis: The samples were stored deep-frozen and protected from light until analysis was performed.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test medium with a loading rate of nominal 100 mg/L was prepared prior to the start of the test and prior to each test medium renewal by weighing nominal 500 mg of the test item into 5000 mL of test water. No auxiliary solvent or emulsifier was used. The test item was mixed into the test water as homogeneously as possible using ultrasonic treatment for 15 minutes and intense stirring for 96 hours at room temperature in the dark to dissolve a maximum concentration of the test item in the dispersion. The long stirring period of 96 hours was chosen according to the results of a pre-test (without GLP) which showed that during this time no significant loss of the test item was to be expected. Then, the supersaturated stock dispersion of the test item was filtered through a membrane filter (Schleicher & Schuell, Type NC45, pore size 0.45 pm) after the 96 hours stirring period just before the preparation of the test medium. The undiluted filtrate with the maximum concentration of dissolved test item was used as test medium.
- Differential loading: 100 mg/L
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): No auxiliary solvent or emulsifier was used.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra fish (Brachydanio rerio)
- Source: supplier H. Eggimann, CH-4133 Prattein, Switzerland
- Length at study initiation: 2.8 ± 0.22 cm (Mean ± SD)
- Weight at study initiation: 0.18 ± 0.04 g (Mean ±SD)
- Feeding during test: Fish were not fed during the test
ACCLIMATION
- Acclimation period: 1 week
- Acclimation conditions (same as test or not): yes
- Type and amount of food: commercial fish diet
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 125 mg/L as CaCO3;
- Test temperature:
- 21 - 22 °C;
- pH:
- 7.1 - 7.3;
- Dissolved oxygen:
- 8.4 - 9.0 mg/L;
- Salinity:
- alkalinity: 0.4 mmol/L;
- Nominal and measured concentrations:
- Nominal loading rate: 100 mg/L
Measured: 0.80 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: One glass aquarium with five liters test medium was used for each treatment (the single test concentration and the control)
- Renewal rate of test solution: daily
- No. of organisms per vessel: 7 fish per vessel
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted test water according to the Commission Directive 92/69/EEC and the OECD Guideline.
OTHER TEST CONDITIONS
- Adjustment of pH: 7.1 - 7.3
- Photoperiod: Photoperiod of 16 hours light and 8 hours darkness (with a 30 minute transition period). The test was performed under reduced light conditions to avoid photolytic degradation of the test item (< 50 LUX)
TEST CONCENTRATIONS
- Justification for using less concentrations than requested by guideline: According to the results of a pre-experiment (without GLP) the test item was not soluble at a concentration of 100 mg/L in test water and no homogeneous dispersion could be prepared.
A limit test was performed in accordance with the test guidelines to demonstrate that the test item has no toxic effect on the test fish up to the highest concentration which could be dissolved in the test water at a loading rate of 100 mg/L. Additionally, a control (test water without test item) was tested in parallel. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: masured: 0.80 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: measured: 0.80 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: measured: 0.80 mg/L
- Details on results:
- - Behavioural abnormalities: None observed
- Mortality of control: None;
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Since WAFs were prepared, all reported biological results are related to the loading rate of 100 mg/L of the test item.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- With high probability not acutely harmful to fish. No toxic effects within the range of solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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