Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 275-654-5 | CAS number: 71598-17-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
According to column 2 (section 8.1) of REACH Regulation Annex VII and due to animal welfare reasons the study for skin irritation and eye irritation can be waived as the test item causes severe skin burns and is classified as Skin Corr. 1B; H314.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- other justification
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- other justification
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The registered substance contains ca. 33% (w/w) free acetic acid. Acetic acid (CAS 64-19-7) is classified as corrosive to skin according to Annex VI of Regulation (EC) No 1272/2008 (Skin Corr. 1A; H314). Taking into account the specific concentration limits for acetic acid, the registered substance needs to be classified as Skin Corr. 1B; H314 (SCL: 25% ≤ C < 90%). According to column 2 (section 8.1) of REACH Regulation Annex VII studies for skin and eye irritation can be waived as the test item is assessed to be corrosive to the skin.
Already existing studies are available where the registered substance was tested in a composition of 24 % active ingredient, 20 % acetic acid. The free acid content in these studies is lower than the free acid in the composition of the registered substance. Therefore, the results from these studies are not representative for the assessment of this endpoint.
Skin irritation
BASF SE 1978 (77/126)
4 males and 2 females received the test item unchanged in a mixture of 24 % active substance and 20 % acetic acid. Irritation scores were measured after 24, 72 hours and 8 days. The erythema index could not be read and calculated exactly due to substance-induced coloration of the skin. The edema score (mean score after 24 and 72 h) was calculated to be 1 and 1.5 after scarification. Scores are indicated as mean values for all animals.
BASF SE 1987 (16H0251/872141)
The test was carried out in equivalence to OECD guideline 404. One male and 2 female rabbits received the test item (CAS 71598 -17-9) unchanged on the clipped skin test site. The area of exposure was 2.5 cm x 2.5 cm. The test item was applied semiocclusively in a mixture consisting of 24 % active substance and 20 % acetic acid. The composition was applied in an amount of 0.5 mL over a period of 3 min and 1 hour. At the end of the exposure period the test substance was removed with Lutrol and water. The animals were observed for 30-60 min, 24 h, 48 h and 72 h. No erythema score could be calculated after 1h exposure time due to violet coloration caused by the material. The erythema score after 3 min exposure time was 0, also the edema score was 0 after 3 min and 1 h exposure time.
BASF SE 1987 (18H0251/872270)
The test was carried out in equivalence to OECD guideline 404. One male and 2 female rabbits received the test item (CAS 71598-17-9) unchanged on the clipped skin test site. The area of exposure was 2.5 cm x 2.5 cm. The test item was applied semiocclusively in a mixture consisting of 24 % active substance and 20 % acetic acid. The test item was applied in an amount of 0.5 mL over a period of 4 hours. At the end of the exposure period the test substance was removed with Lutrol and water. The animals were observed for 24 h, 48 h and 72 h. No erythema score could be calculated due to violet coloration caused by the material. The edema score was 0.
Eye irritation
Supporting
BASF SE 1978 (Report No. 77/126)
In a study equivalent to OECD guideline 405 the eye irritation with 5 male and 1 female rabbits was tested. The test item (CAS 71598-17-9) was applied in a mixture consisting of 24 % active substance and 20 % acetic acid. The animals were observed over a period of 8 days. Eye irritation was evaluated according to the criteria of Draize et al.
The mean scores at 24, 48 and 72 h for all animals were as following:
Cornea: 1.567
Iris: 0.22
Conjunctivae: 1.83
Chemosis: 2.72
The effects were not reversible.
Justification for classification or non-classification
The registered substance is a multi-constituent substance which contains acetic acid at ca. 33%. Acetic acid (CAS 64-19-7) is classified as corrosive to skin and eye according to Annex VI of Regulation (EC) No 1272/2008 (Skin Corr. 1A; H314). Taking into account the specific concentration limits for acetic acid, classification of the registered substance with Skin Corr. 1B; H314 is warranted under Regulation (EC) No 1272/2008 (SCL: 25% ≤ C < 90%). Furthermore, in two supporting in vivo eye irritation studies irreversible eye damage was observed supporting corrosive properties of the registered substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.