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EC number: 223-358-1 | CAS number: 3852-09-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A skin irritation study was performed with rabbits. A single semi-occlusive application of methyl-3-methoxy propionate to intact rabbit skin for 4 hrs elicited transient mild dermal irritation. Very slight erythema was observed in 3 animals following the removal of the dressings on day 1 and for the following 2 days. All reactions had resolved by day 4.
No erythema was observed in the remaining 3 animals. No oedema was observed in any of the 6 animals.
Anin vivostudy demonstrated that methyl-3 -methoxy propionate is an eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- An in vitro study was not conducted since an in vivo study was already available. The in vivo study was conducted in 1990.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield Farms Ltd., Petersfield, Hampshire, UK
- Age at study initiation: 11-13 weeks
- Weight at study initiation: 2.4-3.0 kg prior to treatment on day 1
- Housing: individually housed
- Acclimation period: yes
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approximately 19
- Humidity (%): 30-70
- Air changes (per hr): approximately 19
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 10 cm2
REMOVAL OF TEST SUBSTANCE
- Washing: with water - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Irritant / corrosive response data:
- Very slight erythema only was observed in 3 animals following the removal of the dressings on day 1 and for the following 2 days. All reactions had resolved by day 4. There was no response to treatment in the remaining 3 animals.
- Conclusions:
- A single semi-occlusive application of methyl-3-methoxy propionate to intact rabbit skin for 4 hours elicited transient mild dermal irritation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation, other
- Remarks:
- An in vitro study was not conducted since an in vivo study was already available. The in vivo study was conducted in 1990.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Froxfield Farms Ltd., Petersfield, Hampshire, UK
- Age at study initiation: 11-13 weeks
- Weight at study initiation: 2960 g prior to treatment on day 1
- Housing: individually housed
- Acclimation period: yes
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approximately 19
- Humidity (%): 30-70
- Air changes (per hr): approximately 19
- Photoperiod (hrs dark / hrs light): 12/12 - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL - Observation period (in vivo):
- 14 days
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- TOOL USED TO ASSESS SCORE: handheld torch
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 1 - <= 2
- Reversibility:
- fully reversible within: 14
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 1 - <= 2
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- A corneal opacity had developed the day following instillation but had resolved 14 days following instillation.
Irridial inflammation was only present 3 and 4 days after instillation.
A diffuse crimson-red colouration of the conjunctivae accompanied by obvious swelling with partial eversion of the eyelids was observed. - Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Instillation of methyl-3-methoxypropionate into the eye of one rabbit elicited a positive response.
- Executive summary:
0.1 mL methyl-3 -methoxypropionate was applied to one eye of a rabbit. A corneal score >1 and a conjuntival redness score of 2 were calculated as the mean scores following grading after 1, 2 and 3 days. The effects were reversible within 14 days. These effects warrant a classification as eye irritant.
Due to the intensity of the response no further animals were exposed to the test substance.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
Since only slight (maximum observed score = 1) and transient erythema was observed in an in vivo skin irriation test, methyl-3-methoxy propionate is not classified for skin irritation/corrosion.
Methyl-3 -methoxypropionate was tested for eye irritation/corrosion in an in vivo test. A corneal score >1 and a conjuntival redness score of 2 were calculated as the mean scores following grading after 1, 2 and 3 days. The effects were reversible within 14 days. These effects warrant a classification as eye irritant.
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