Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-778-7 | CAS number: 150-90-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- disodium succinate
- Type of composition:
- boundary composition of the substance
- State / form:
- solid: bulk
- Reference substance:
- disodium succinate
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Classification of Disodium succinate for effects in the environment:
The chemical Disodium succinate (CAS no. 150-90-3) is used as an acidulant and flavouring agent for foods & as a protective coating for fruits and vegetables. It is also used as a chemical intermediate.The aim was to assess whether the PBT criterion within Annex XIII was fulfilled for Disodium succinate. The PBT criterion was herein assessed based on experimental data in conjunction with standardized environmental fate models. Here follows a description of the PBT assessment.
Persistence assessment
The tested substance does not fulfils the P criterion within Annex XIII based on the assessment that here follows:
Biotic degradation
Various experimental key and supporting studies of the test chemical were reviewed for the biodegradation end point which are summarized as below:
In an experimental key study from study report (2018), 28-days Closed Bottle test following the OECD guideline 301 D to determine the ready biodegradability of the test chemical. The study was performed at a temperature of 20°C. The test system included control, test item and reference item. Polyseed were used for this study. The concentration of test and reference item (Sodium Benzoate) chosen for both the study was 4 mg/L, while that of inoculum was 32 ml/l. OECD mineral medium was used for the study. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % degradation was calculated using the values of BOD and ThOD for test item and reference item. The % degradation of procedure control (reference item) was also calculated using BOD & ThOD and was determined to be 76.5%. Degradation of Sodium Benzoate exceeds 45.18% on 7 days & 70.48% on 14th day. The activity of the inoculum was thus verified and the test can be considered as valid. The BOD28 value of test chemical was observed to be 0.67 mgO2/mg. ThOD was calculated as 0.69 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to Closed Bottle test was determined to be 97.1%. Based on the results, the test item, under the test conditions, was considered to be readily biodegradable in nature.
For the test chemical, the Biodegradation experiment was carried out for determining biodegradability of test chemical following the OECD Guideline 301 C "Ready Biodegradability: Modified MITI Test (I)" under aerobic conditions (from authoritative database, handbook and secondary source, 2018). In this experiment, non-adapted activated sludge was used as test inoculum for the study at 30 mg/L concentration. Aniline was used as a reference substance for the study. The initial concentration of test chemical was 100 mg/L. Biodegradation was analyzed by using three parameters namely O2 consumption (BOD), TOC removal and test material analysis by HPLC. After 14 days of incubation, percent biodegradation of test chemical was determined to be 72 % by O2 consumption (BOD) parameter 100 % by TOC removal and test material analysis by GC parameter, respectively. Therefore, it is concluded that test chemical is considered to be readily biodegradable in water.
On the basis of above results for test chemical Disodium succinate, it can be concluded that the test chemical can be considered to be readily biodegradable in natureand thus likely to be not persistent (not P) in nature.
Environmental fate
According to the fugacity model levels III, the most likely environmental fate for this test chemical is soil (i.e.estimated to 70.7%). In soil,Disodium succinatewas expected to have rapid mobility based upon a Log KOC value of 1.078, respectively. The half-life in soil (17.33 days estimated by EPI suite) indicates that the chemical is not persistent in soil and the exposure risk to soil dwelling animals is moderate to low.
If released in to the environment, 29.3% and 0.0587% of the chemical will partition into water & sediment according to the Mackay fugacity model level III in EPI suite version 4.1 (2017). However, the half-life (8.66 days in water and 77.916 days in sediment estimated by EPI suite) indicates that the chemical is not persistent in water & sediment and the exposure risk to aquatic & sediment dwelling animals is moderate to low.
Hence it has been concluded that Disodium succinate is not persistent in nature.
Bioaccumulation assessment
The tested substance does not fulfil the B criterion within Annex XIII based on the assessment that here follows:
The estimated BCF value from authoritative databases was determined to beranges from 3.162 to 3.89, respectively and the octanol water partition coefficient of the test chemical was determined to -0.56 to -0.59, respectively, which is less than the threshold of 4.5. If this chemical is released into the aquatic environment, there should be a low risk for the chemical to bioaccumulate in fish and food chains.
Toxicity assessment
The tested substance does not fulfil the T criterion within Annex XIII based on the assessment that here follows:
Mammals
The tested chemical is regarded to be not classified for carcinogenicity, mutagenicity and reprotoxicity, Further, there is no evidence of chronic toxicity, as identified by the classifications STOT (repeated exposure), category 1(oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume) or category 2 (oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume).
Aquatic organisms
All of the available short-term eco-toxicity data for fish, invertebrates and algae for the substanceDisodium succinateindicates the LC50/EC50 value to be in the range 100.99 to > 1000 mg/L, respectively and on the basis ofthe available data oflong term eco-toxicity data for aq. Invertebrates, both the NOEC and EC50 value was determined to be ranges from > 100 mg/l, respectively. These value suggest that the substance is likely to be not hazardous to aquatic organisms at environmentally relevant concentrations and can be considered to be ‘not classified’ as per the CLP regulation.
By speculation, long-term NOEC for aquatic organisms were not expected for the substance at concentration below 0.01 mg/L based on the data mentioned above.
The chemical was therefore not considered as hazardous to aquatic environments as per the criteria set out in Annex XIII.
Conclusion
Based on critical, independent and collective evaluation of information summarized herein, the tested compound does not fulfil the P, B and T criterion and has therefore not been classified as a PBT compound within Annex XIII.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.