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EC number: 943-502-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 4 Jul 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Version / remarks:
- reported as EG-guideline 88/302/EG (30.05.1988)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Stock solution (5000,3 mg test substance in VE water) ad 200 mL (VE-Water) plus 200 µL Baysilone (foam killer) - Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Source: Municipal sewage treatment plant "Marl-West"
- Preparation of inoculum for exposure: sludge was sampled, allowed to settle, washed with 2 L tap water, aerated for 30 min and stirred; 200 mL synthetic effluenct were added to the cleaned sludge and tap water added ad 4 L
- Pretreatment: On test day, the sludge was allowed to settle and was washed twice with 2 L tap water
- Initial biomass concentration: 3.82 g dry substance/L - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- not relevant
- Hardness:
- no data
- Test temperature:
- 20 ± 2 °C
- pH:
- 8.0-8.4
- Dissolved oxygen:
- >2.5 mg/L
- Salinity:
- not relevant
- Nominal and measured concentrations:
- Nominal: 0, 260, 390, 578.5, 864.5 and 1300 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 500 mL beaker
- Renewal rate of test solution (frequency/flow rate): none
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 2
- No. of vessels per reference control (replicates): 3
- Culture medium different from test medium: no
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : oxygen consumption rate (manometric)
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.5 - Reference substance (positive control):
- yes
- Remarks:
- Dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 680 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: EC50 between 5 and 30 mg/L (test result: 8.1 mg/L) - Reported statistics and error estimates:
- Excel, program auswert.msk, probit and logarithm of concentration calculated, results from linear section of regression curve
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the Category Approach Justification document provided in IUCLID6 Section 13
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 680 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: read-across from CAS 68955-19-1
Referenceopen allclose all
Description of key information
3h EC50 (activated sludge, domestic) = 680 mg/L (respiration inhibition test, EU method C.11)
Key value for chemical safety assessment
- EC50 for microorganisms:
- 680 mg/L
Additional information
Since no reliable toxicity tests with microorganisms are available for C14-16AS Na (CAS 91648-54-3), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to another structurally related category member was conducted. Read-across data from C12-18AS Na (68955-19-1) were used.
In the GLP-study with C12-18AS Na (CAS 68955-19-1) conducted according to the EU method C.11, an EC50 of 680 mg a.i./L is reported for the respiration rate after 3 h of exposure.
Due to structure and property similarities with the tested category member it can be concluded that the above result applies also to C14-16AS Na (CAS 91648-54-3). The 3h EC50 value for microorganisms is considered to be 680 mg/L. This value was used for the PNEC STP derivation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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