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Diss Factsheets
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EC number: 248-702-8 | CAS number: 27870-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from United States Environmental Protection Agency
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity study of 1-Hexadecanamine, N,N-dimethyl- in Rabbit
- Author:
- Calandra, J. C.
- Year:
- 2 016
- Bibliographic source:
- US EPA (United States Environmental Protection Agency), High Production Volume Information System (HPVIS), 2016.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute dermal toxicity study of 1-Hexadecanamine, N,N-dimethyl- in Rabbit
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Hexadecyldimethylamine
- EC Number:
- 203-997-2
- EC Name:
- Hexadecyldimethylamine
- Cas Number:
- 112-69-6
- IUPAC Name:
- N,N-dimethylhexadecan-1-amine
- Reference substance name:
- 1-Hexadecanamine, N,N-dimethyl-
- IUPAC Name:
- 1-Hexadecanamine, N,N-dimethyl-
- Details on test material:
- - Name of test material (as cited in study report): 1-Hexadecanamine, N,N-dimethyl-
- Molecular formula (if other than submission substance): C18H39N
- Molecular weight (if other than submission substance): 269.513 g/mole
- Substance type: Organic
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: averaging 2.5 kg/bw
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- The test substance was administered undiluted. The hair on the backs of young, adult rabbits was clipped twenty-four hours prior to test substance administration. The test substance was applied to the back of each rabbit and gently, but thoroughly, rubbed into the exposure site and the site occluded with impervious plastic sheeting for 24 hours. Rabbits were observed for signs of toxicity for 14 days following removal of the plastic sheeting and excess test substance.
- Duration of exposure:
- once
- Doses:
- 2200, 3300 and 4400 mg/kg bw
- No. of animals per sex per dose:
- Total: 12
2200 mg/kg bw: 4 rabbits
3300 mg/kg bw: 4 rabbits
4400 mg/kg bw: 4 rabbits - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: No data available - Statistics:
- The method of Litchfield and Wilcoxon was used to determine the range-finding acute percutaneous mean lethal dose together with the LD0.01 and LD99.99
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 359.5 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 705 - 3 355
- Remarks on result:
- other: No 50 % mortality observe d
- Mortality:
- When treated with 4400 mg/kg bw, Between 24 and 48 hours post dose, rabbit became extremely weak, lethargic and in a moribund state. These rabbits died within the next few hours.
When treated with 2200 and 3300 mg/kg bw, rabbits survived until study termination eventually showed signs of recovery. - Clinical signs:
- other: No signs of toxicity were observed in the rabbits during the first six hours following test substance administration. Rabbits in all dose groups showed signs of generalized weakness and lassitude, and did not eat or drink 24 hours post dose. Signs of slig
- Gross pathology:
- No significant gross pathological changes were observed in treated rabbits.
- Other findings:
- No data available
Any other information on results incl. tables
Dose group |
Number of deaths |
2200 mg/kg bw |
2/4 |
3300 mg/kg bw |
3/4 |
4400 mg/kg bw |
4/4 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- LD50 was considered to be 2359.5 mg/kg bw (95% confidence limits = 1705 to 3355 mg/kg bw) when New Zealand White rabbits were treated with 1-Hexadecanamine, N, N-dimethyl- dermally.
- Executive summary:
In a acute dermal toxicity study,New Zealand White rabbits were treated with 1-Hexadecanamine, N, N-dimethyl- dermally and observed for 14 days. At 4400 mg/kg bw., between 24 and 48 hours post dose, rabbit became extremely weak, lethargic and in a moribund state. These rabbits died within the next few hours. At 2200 and 3300 mg/kg bw, rabbits survived until study termination eventually showed signs of recovery. No signs of toxicity were observed in the rabbits during the first six hours following test substance administration. Rabbits in all dose groups showed signs of generalized weakness and lassitude, and did not eat or drink 24 hours post dose. Signs of slight transient erythema, and appeared dried, leathery and wrinkly were also observed in treated rabbits. At 2200 and 3300 mg/kg bw, hair loss and considerable decrease in body weight was observed in treated rabbits. No significant gross pathological changes were observed in treated rabbits. Therefore,LD50 was considered to be2359.5 mg/kg bw (95% confidence limits = 1705 to 3355 mg/kg bw) when New Zealand White rabbits were treated with 1-Hexadecanamine, N, N-dimethyl- dermally.
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