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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: similar to guideline study, but prior to establishment of guideline protocols and GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Version / remarks:
was conducted prior to establishment of guideline method
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpyridine
EC Number:
203-643-7
EC Name:
2-methylpyridine
Cas Number:
109-06-8
Molecular formula:
C6H7N
IUPAC Name:
2-methylpyridine

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 h
Doses:
79.4, 200, 316, 501, 1000 and 2000 mg/kg bw
No. of animals per sex per dose:
1
Control animals:
no
Details on study design:
gross necropsy on animals which succumbed during study and on surviving animals sacrificed after the conclusion of the experiment.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 200 - < 316 mg/kg bw
Based on:
test mat.
Mortality:
Animals given 79.4 and 200 mg/kg bw survived. Animals given 316 and 501 mg/kg bw died after 1 day, and those given 1000 and 2000 mg/kg bw died after 16 hours.
Clinical signs:
other: reduced appetite and activity, rapidly increasing weakness, collapse and death
Gross pathology:
hemorrhagic lungs, slightly discolored liver and gastrointestinal inflammation. There were no abnormalities in surviving animals.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
An acute dermal toxicity test was conducted using occlusive exposure conditions using one albino rabbit at each of six doses of 2-methylpyridine. The LD50 was greater than 200 and less than 316 mg/kg bw.