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EC number: 290-923-7 | CAS number: 90294-39-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to aquatic invertebrates
EC50 = 146 mg/l
Toxicity to aquatic plants other than algae
ErC50 = 50 mg/l
Additional information
No studies on the "Aquatic toxicity" are available for the substance in itself.
Nevertheless studies have been conducted with an analogue molecule (Similar Substance 01). Further information are reported in the Read Across justification attached to section 13.
Different available tests may be considered that give information on Aquatic toxicity.
Short-term toxicity to aquatic invertebrates
The acute toxicity of the Similar Substance 01 to Daphnia magna was determined in a 48-hour static test according to the OECD Guideline 202. The study was performed in compliance with the GLP. The nominal concentrations tested were 45, 100 and 220 mg test article/l, a vehicle and a blank control without any addtions. In all test concentrations non alteration of the test substance was observed after 48 hours. During the test the concentrations in the analysed test media were in the range of 87 - 95 % of the nominal values. Therefore, the reported results are related to the actual mean values of the analysed concentrations of the test article in the test medium, measured at the beginning and at the end of the test. No immobilization and abnormal behaviour of the Daphnia was observed in the controls. The EC50 after 48 h was 146 mg/l, the NOEC and EC0 value were determined to be 39 mg/l, the EC100 value is > 203 mg/l.
Toxicity to aquatic plants other than algae
A study was performed to assess the effect of the Similar Substance 01 on the growth of the freshwater plant Lemna minor according to the OECD Guideline No. 221.
Following a preliminary range-finding test, Lemna minor was exposed to an aqueous solution of the test item at nominal concentrations of 1.0, 3.2, 10, 32 and 100 mg active ingredient (a.i.)/l.
The number of fronds in each control and treatment group was recorded on days 0, 3, 5 and 7 along with observations on plant development.
Chemical analysis of the test preparations on Day 0 (fresh media) showed measured test concentrations to range from 0.90 to 95 mg/l. A slight decline in measured test concentration was observed on Day 7 in the range of 0.46 to 88 mg/l.
Given this decline in measured test concentrations it was considered justifiable to base the results on the geometric mean measured test concentrations in order to give a “worst case” analysis of the data.
Exposure of Lemna minor to the test item based on the geometric mean measured test concentrations gave the following results:
The average specific growth rate (frond number) EC50 was 82 mg ai/L.
The average specific growth rate (dry weight) EC50 was 50 mg ai/L.
The yield (frond number) EC50 was 17 mg ai/L.
The yield (dry weight) EC50 was 13 mg ai/L.
The NOEC was 0.64 mg/L and the LOEC was 2.3 mg ai/L.
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008), Part 4: Environmental Hazards, the substances can be classified for hazardous to the aquatic environment (fish toxicity) when the following criteria are met:
A )Acute (short-term) aquatic hazard
Category Acute 1:
96 hr LC 50 (for fish) ≤ 1 mg/l and/or
48 hr EC 50 (for crustacea) ≤ 1 mg/l and/or
72 or 96 hr ErC 50 (for algae or other aquatic plants) ≤ 1 mg/l
B) Long-term aquatic hazard
(iii) Substances for which adequate chronic toxicity data are not available
Category Chronic 3:
96 hr LC 50 (for fish) > 10 to ≤ 100 mg/l and/or
48 hr EC 50 (for crustacea) > 10 to ≤ 100 mg/l and/or
72 or 96 hr ErC 50 (for algae or other aquatic plants) > 10 to ≤ 100 mg/l
and the substance is not rapidly degradable and/or the experimentally determined BCF ≥ 500 (or, if absent, the log K ow ≥ 4).
Based on the above results the Lemna study provides the lowest toxicity endpoint and will be used for Classification. Therefore the test substance is Classified as Category Chronic 3.
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