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Diss Factsheets
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EC number: 805-580-6 | CAS number: 1431696-36-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- benzyltrimethylazanium 2-hydroxy-2-methylpropanoate
- EC Number:
- 805-580-6
- Cas Number:
- 1431696-36-4
- Molecular formula:
- C14 H23 O3 N
- IUPAC Name:
- benzyltrimethylazanium 2-hydroxy-2-methylpropanoate
- Details on test material:
- - Identification: BTMA-HIB
- Chemical name: N,N,N-trimethyl -, 2-hydroxy- 2-methylpropanoate (1:1)
- Physical form: solid
- Water solubility: Miscible
- Purity: >90%; treated as 100% pure
- Storage conditions: at room temperature, under N2
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Observations of immobile Daphnia were made after 24 and 48 h of exposure.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Prior to the definitive test, a non-GLP range finding test with nominal concentrations
of BTMA-HIB of 1, 10 and 100 mg/l was performed.
Based on the results of this range finding test, the following nominal test
concentrations of BTMA-HIB for the definitive test were selected: 5, 10, 20, 40, 80
and 160 mg/l.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna STRAUS
- Age: less than 24 h
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 2.52 mmol/l
- Test temperature:
- 22°C
- pH:
- 7.1-7.4
- Dissolved oxygen:
- 6.0-6.5 mg/L
- Details on test conditions:
- - Light: 16 h photoperiod a day, supplied by oberhead white fluorescent tubes
- Medium: Contious aerated Elendt M4 medium; prepared with deionised water (conductivity <1.5 µS/cm)
- Feed: Suspension of Desmodesmus subspicatus in Elendt M4 medium with an optical density OD680 of about 15 units; 400 μl per Daphnia per day, except on weekends
- Control of sensitivity: Acute reference test with potassium dichromate conducted twice a year
- Number of Daphnia: 40 individuals per test concentration, 20 per vessel
- Test vessel: 100 ml flasks, all-glass, with 50 ml of test medium
- Replicates: 2 replicates with test animals (20 animals per replicate); 3 replicates as blank controls - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 93.6 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 72.4-132
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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