Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-525-1 | CAS number: 13826-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism in Rats of 3-Phenoxybenzyl Alcohol and 3-Phenoxybenzoic Acid Glucoside Conjugates Formed in Plants
- Author:
- Nobuyoshi Mikami, Jun Yoshimura, Hideo Kaneko, Hirohiko Yamada and Junshi Miyamoto
- Year:
- 1 985
- Bibliographic source:
- Pestic. Sci. 1985, 16, 33-45
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- The objective of the experiment was to study the metabolism in Rats of 3-Phenoxybenzyl Alcohol
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-phenoxybenzylic alcohol
- EC Number:
- 237-525-1
- EC Name:
- 3-phenoxybenzylic alcohol
- Cas Number:
- 13826-35-2
- Molecular formula:
- C13H12O2
- IUPAC Name:
- (3-phenoxyphenyl)methanol
- Details on test material:
- [14C]3-Phenoxybenzyl alcohol
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 10% Tween 80 (1 ml)
- Details on exposure:
- The specific-pathogen free (SPF) and germ-free rats were each given a single oral dose of the 14C-preparations of 3-Phenoxybenzyl alcohol in 10% Tween 80 (1 ml) at a rate of 9 µmol kg-1. The SPF rats were individually housed in all-glass metabolism cages. The urine and faeces were collected separately for 1 day (germ-free rats), and for up to 7 days (SPF rats). At least four SPF and two germ-free rats were sacrificed at specified intervals for determination of 14C excretion and tissue residues, or for characterisation of the I4C metabolites.
- Duration and frequency of treatment / exposure:
- 7 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
9 µmol kg-1
- No. of animals per sex per dose / concentration:
- No data
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- 3-phenoxybenzyl alcohol was absorbed from the gastrointestinal tracts of the SPF rats.
- Type:
- distribution
- Results:
- Metabolites formed were distributed in the urine, bile and faeces.
- Type:
- metabolism
- Results:
- Following absorption, 3-phenoxybenzyl alcohol was rapidly oxidised to 3-phenoxybenzoic acid.
- Type:
- excretion
- Results:
- 99.4 (+ 0.6) of the administered radioactivity was excreted after 7 days of administration
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 3-phenoxybenzoic acid and
3-(4-sulphonyloxyphenoxy)benzoic acid
Any other information on results incl. tables
Further details on metabolism
Following absorption, 3-phenoxybenzyl alcohol was rapidly oxidised to3-phenoxybenzoic acid. The acid was further metabolised by direct conjugation with glucuronide, and by hydroxylation primarily at the 4-position of the phenoxy ring, and subsequent conjugation with glucuronide and sulphate. The sulphate ester
3-(4-sulphonyloxyphenoxy)benzoic acid was rapidly eliminated in the urine, while the glucuronides were excreted in the bile and then cleaved in the gastrointestinal tract to afford 3-(4-hydroxyphenoxy)benzoic acid, which was reabsorbed and excreted in the urine as 3-(4-sulphonyloxyphenoxy)benzoic acid. These results were in good accord with those of the previous report. The sulphate conjugate 3-(4-sulphonyloxyphenoxy)benzoic acid was also excreted in the bile but to a lesser extent.However, it was fairly resistant to hydrolysis by the gut microflora, as compared with the glucose and glucuronide conjugates, and consequently corstituted a main metabolite of the intestinal contents and faeces
of the SPF rats. The sulphate codjugate 3-(4-sulphonyloxyphenoxy)benzoic acid was also a main faecal metabolite of the germ-free rats.
Meanwhile, the major metabolites were3-phenoxybenzoic acidand 3-(4-sulphonyloxyphenoxy)benzoic acid in the liver, and3-phenoxybenzoic acidin the blood.
3-Phenoxybenzyl alcohol (I) rapidly declined to the non-detectable level because of its rapid conversion to3-phenoxybenzoic acid.
Further details on excretion
The radioactivity excreted in the urine and faeces of SPF intact rats as % of the dose administered, following single oral administration of14C-3-phenoxybenzy1 alcohol is presented below:
0-1 day
In urine: 85.9 (+3.3)
In Feaces: 10.1(+3.3)
Total: 95.9 (+0.1)
0-7 days
Total: 99.4(+0.6)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
In an experiment to study the metabolism in Rats of 3-Phenoxybenzyl Alcohol, male SD rats were given a single oral dose of the 14C-preparations of 3-Phenoxybenzyl Alcohol in 10% Tween 80 (1 ml) at a rate of 9 µmol kg-1. The administered 3-Phenoxybenzyl Alcohol was absorbed in the GI tract and metabolized to 3-phenoxybenzoic acid and 3-(4-sulphonyloxyphenoxy) benzoic acid. At the end of 7 days, a total of 99.4 (+ 0.6) of the % of the dose administered was excreted out of the body of rats in urine and feaces.
Thus, it is concluded that the bioaccumulation potential of the chemical 3-Phenoxybenzyl Alcohol is expected to be low. - Executive summary:
In an experiment to study the metabolism in Rats of 3-Phenoxybenzyl Alcohol, male SD rats weregiven a single oral dose of the14C-preparationsof 3-Phenoxybenzyl Alcoholin 10% Tween 80 (1 ml) at a rate of 9 µmol kg-1. The administered3-Phenoxybenzyl Alcohol was absorbed in the GI tract and metabolized to3-phenoxybenzoic acidand 3-(4-sulphonyloxyphenoxy)benzoic acid. At the end of 7 days, a total of 99.4(+0.6)of the % of the dose administered was excreted out of the body of rats in urine and feaces.
Thus, it is concluded that the bioaccumulation potential of the chemical3-Phenoxybenzyl Alcoholis expected to be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.