Registration Dossier
Registration Dossier
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EC number: 406-260-5 | CAS number: 58834-75-6 BTN; VPO CATALYST
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessed after consultation with the relevant Authority. Data migrated from NONS files provided by Authority contain insufficient information.
Data source
Reference
- Reference Type:
- other: no data
- Title:
- Unnamed
- Report date:
- 1991
Materials and methods
- Principles of method if other than guideline:
- Chromosome aberration in vivo
- GLP compliance:
- not specified
- Type of assay:
- other: Non-bacteriological test in vivo - 6th amendment data
Test material
- Reference substance name:
- Vanadyl pyrophosphate
- EC Number:
- 406-260-5
- EC Name:
- Vanadyl pyrophosphate
- Cas Number:
- 58834-75-6
- Molecular formula:
- O9P2V2
- IUPAC Name:
- divanadium(4+) (phosphonatooxy)phosphonate dioxidandiide
- Details on test material:
- - Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500, 1000, 2000 mg/kg
Basis:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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