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Diss Factsheets
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EC number: 233-546-5 | CAS number: 10226-30-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Cycloalkanones. 7. Hypocholesterolemic Activity of Aliphatic Compounds Related to 2,8-Dibenzylcyclooctanone
- Author:
- G. L. Carlson,I. H. Hall, and C. Piantadosi
- Year:
- 1 975
- Bibliographic source:
- Journal of Medicinal Chemistry, 1975, Vol. 18, No. 10 pp 1024-1026
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as per below mentioned
- Principles of method if other than guideline:
- The repeated dose toxicity test was conducted on chemical 2-octanone exposed to CF1 mice intraperitonially daily with dose concentration of 50 mg/kg/day.
- GLP compliance:
- no
Test material
- Reference substance name:
- 111-13-6
- IUPAC Name:
- 111-13-6
- Reference substance name:
- Octan-2-one
- EC Number:
- 203-837-1
- EC Name:
- Octan-2-one
- Cas Number:
- 111-13-7
- IUPAC Name:
- octan-2-one
- Details on test material:
- - Name of test material: Octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.21 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: Carworth Farms
- Age at study initiation: No data available
- Weight at study initiation: No data available
- Fasting period before study:
- Housing: No data available
- Diet (e.g. ad libitum): ): Purina lab chow
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 1% carboxymethylcellulose- H20(CMC)
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
Test compound was suspended in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized. Doses (mg/kg) were calculated on daily weights of the mice
VEHICLE
- Justification for use and choice of vehicle (if other than water):No data available
- Concentration in vehicle:50 mg/kg/day
- Amount of vehicle (if gavage):1% - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 19.4 days
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 mg/kg/day
- No. of animals per sex per dose:
- No data available
- Control animals:
- other: Control animals were given 1% carboxymethylcellulose- H20 (CMC) only
- Details on study design:
- No data available
Examinations
- Observations and examinations performed and frequency:
- Observations and examinations performed & frequency
CAGE SIDE OBSERVATIONS: No data
DETAILED CLINICAL OBSERVATIONS: No data
-
BODY WEIGHT: No data
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study):
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No data
- Compound intake calculated as time-weighted averages from the consumption and body weight gain data: No data
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): No data
OPHTHALMOSCOPIC EXAMINATION: No data
HAEMATOLOGY: No data
URINALYSIS: No data
NEUROBEHAVIOURAL EXAMINATION: No data
OTHER: The percent pregnant, the number of viable fetuses per litter, and the number of reabsorption sites and dead in utero per litter were noted and expressed as a percent of the control value. - Sacrifice and pathology:
No data available- Statistics:
- the number of animals in a group, expressed as N, the mean of the percent of control, and standard deviation, expressed as i f S.D.,ar e noted. The probable
significant level ( p ) was determined by the Student's t test according
to the procedure of Snedecor.
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- no antifertility activity was observed at an effective dose level.
The lowered pregnancy rate was observed to 75% of control.
% pregnant %av.no. of fetuses per litter %av no.reabsorption sites per litter
Control 100 100±25 100±25
2-octanone 75 87 0
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Average number of fetuses for CF1,average number of reabsorption sites per litter and lowered pregnancy level.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The no observed adverse effect level(NOAEL) was found to be 50 mg/kg/day in repeated dose toxicity study when exposed to female mice intraperitonially.
- Executive summary:
Subacute toxicity test has been performed on female CF1 female mice.The test chemical was dosed intraperitonially with test concentration of 50 mg/kg /day in 1% carboxymethylcellulose- H20 as a vechicle daily for 19.4 days as gestation . The percent pregnant, the number ofviable fetuses per litter, and the number of reabsorption sites and dead in utero per litter were noted and expressed as a percent of the control value. In our animal quarters, the average gestation time for rodents was 19.4 days with some seasonal variation. The average number of fetuses and reabsorption sites including uterine death for CFI mice was 12 f 3 and 0.48 f 0.12 per litter, respectively. These values were used to calculate the percent of control values for the test compounds. A change greater than 25% is considered to be significant at the level of p = 0.051.test chemical lowered pregnancy level to 75% of control.The no observed adverse effect level(NOAEL) was found to be 50 mg/kg/day in repeated dose toxicity study when exposed to female mice intraperitonially.
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