Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-254-5 | CAS number: 118-47-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Biodegradation in water ability was predicted (SSS QSAR prediction model, 2016) for the test substance Pyrazolone T (CAS no. 118-47-8) using the SSS QSAR prediction model. The ready biodegradability of the test substance Pyrazolone T was estimated as 15.81% in 28 days by using CO2 evolution parameter. This result indicates that Pyrazolone T was estimated to be not readily biodegradable in water.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The predicted data for the test compound Pyrazolone T (CAS no. 118-47-8) and study of its read across substance were reviewed for the biodegradation end point which are summarized as below:
Biodegradation in water ability was predicted (SSS QSAR prediction model, 2016) for the test substance Pyrazolone T (CAS no. 118-47-8) using the SSS QSAR prediction model. The ready biodegradability of the test substance Pyrazolone T was estimated as 15.81% in 28 days by using CO2 evolution parameter. This result indicates that Pyrazolone T was estimated to be not readily biodegradable in water.
Estimation Programs Interface Suite (EPI suite) was run to predict the biodegradation potential of the test compound Pyrazolone T(CAS no. 118-47-8). The screening test inherent to the biodegradability of the substance was calculated using the software BIOWIN v4.10. The results indicate that Pyrazolone T is not expected to be readily biodegradable in nature.
Microbial decomposition of test chemical Food yellow 4 was carried out for 10 days (Yasuhide TONOGAI, 1978). The biodegradation of chemical was determined by 3 methods under aerobic conditions: Aerobic decomposition of dyes with sludge, Oxygen uptake and BOD determination. During 10 days of the aerobic experiment, the absorbance of dye solution was measured once day for 10 days. Only 20% decomposition of test chemical was obtained in10 days. 3.82 O2 mg/hg – sludge oxygen uptake was obtained in 5 –hrs test and the dissolved oxygen contents on the 5th day were essentially the same to initial ones. The low reactivity of aerobic sludge towards dyes was confirmed. Based on the results obtained from the aerobic degradation assay, Warburg method and BOD determination, it can be concluded that tartrazine is not expected to be readily biodegradable under aerobic conditions.
Biodegradation screening test (J-CHECK, 2016) was conducted for 28 days (4 weeks) for evaluating the percentage biodegradability of the test substance Edaravone. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test substance was found to be 0% by BOD, 2% by TOC and 28% by HPLC. Thus, the substance Edaravone is not expected to be not readily biodegradable in water.
On the basis of above results for target and read across substance, it can be concluded that the test substance is not expected to be readily biodegradable in nature.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.