Registration Dossier
Registration Dossier
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EC number: 203-562-7 | CAS number: 108-22-5
Endpoint summary
Administrative data
Description of key information
Isopropenyl acetate is not irritating to skin or eyes under the conditions of the respective OECD in vivo guidelines.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Application of 0.5 g undiluted isopropenyl acetate to the clipped site of 3 New Zealand White rabbits was performed semi-occlusively according to OECD Guideline 404. The test substance was applicated on the clipped dorsal side of the rabbits whereas the other clipped but untreated side saved as a control. The test item showed neither irritant nor corrosive effects on the intact skin of 3 rabbits (strain NZW) after a contact time of 4 hours. 1 hour as well as after 24, 48 and 72 hours no effects were seen on the application site concerning erythema or oedema score. There were no significant body weight changes during the contact and observation period. Considering the reported data of this irritation study it can be stated that the test item Isopropenyl acetate showed no irritant/corrosive effects.
In an eye irritation study with isopropenyl acetate, conducted in accordance with OECD guideline 405, 3 rabbits received an instillation of 0.1 ml undiluted test item into the conjunctival sac of one eye. One hour after treatment all animals were noted to have moderate redness of the conjunctivae and one animal exhibited slight swelling of the conjunctivae. At 24 h only one animal still exhibited mild redness of the conjunctivae, and 48 hours after treatment all animals were without abnormal findings. No other toxic effects were observed.On the basis of the EU directive and based on the results of the test, isopropenyl acetate was evaluated as not irritating to the eye
Effects on respiratory irritation: irritating
Justification for classification or non-classification
On the basis of the EU directive and based on the results of the test, isopropenyl acetate was evaluated as not irritating to the eye
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