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EC number: 235-970-6 | CAS number: 13074-65-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-03-29 - 1982-06-14
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to guideline. Limited substance information (e.g. purity).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Undiluted test substance (10 uL) was applied to one eye of each of two rabbits. Eyes were examined before administration, after 15 minutes treatment, and subsequently at daily intervals. Eyes were graded for corneal, conjunctival and iridial damage.
- GLP compliance:
- not specified
- Remarks:
- The study pre-dates the introduction of GLP in the United Kingdom.
Test material
- Reference substance name:
- 2-n-hexylcyclopentanone
- IUPAC Name:
- 2-n-hexylcyclopentanone
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 2-n-hexylcyclopentanone.
- Substance type: colourless clear liquid.
- Physical state: liquid.
- Analytical purity: no data.
- Impurities (identity and concentrations): no data.
- Composition of test material, percentage of components: no data.
- Isomers composition: no data.
- Purity test date: no data.
- Lot/batch No.: 5.12974T1
- Expiration date of the lot/batch: no data.
- Stability under test conditions: no data.
- Storage condition of test material: refrigerator.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: no data.
- Age at study initiation: 8 weeks.
- Weight at study initiation: 1.6 kg (animal 1) and 1.9 kg (animal 2).
- Housing: individually caged, with no "hay, straw, or similar potentially irritant material".
- Diet (e.g. ad libitum): commercially available, pelleted diet available ad libitum.
- Water (e.g. ad libitum): ad libitum.
- Acclimation period: no data.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data.
- Humidity (%): no data.
- Air changes (per hr): no data.
- Photoperiod (hrs dark / hrs light): no data.
IN-LIFE DATES: no data.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated eye of each animal used as control.
- Amount / concentration applied:
- 10 uL of undiluted test substance applied to one eye of each animal.
- Duration of treatment / exposure:
- Duration of exposure not specified. Study report does not suggest that there was a rinsing step at any point.
- Observation period (in vivo):
- Up to 21 days. Assessments were stopped if the treated eye was judged to have returned to normal.
- Number of animals or in vitro replicates:
- Two.
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified.
- Time after start of exposure: not specified.
SCORING SYSTEM: Please see Attachment 1.
TOOL USED TO ASSESS SCORE: Eyes were examined with the aid of a handtorch for corneal, conjunctival and iridial reactions.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- animal #1
- Remarks:
- Animal number 638, male, 8 weeks, 1.6 kg, treated in right eye
- Time point:
- other: Mean of gradings at 24, 48 and 72 hours.
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- other: Evaluation stopped after 4 days (96 hour timepoint) as eye had returned to normal.
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Remarks:
- Animal number 638, male, 8 weeks, 1.6 kg, treated in right eye
- Time point:
- other: Mean of gradings at 24, 48 and 72 hours
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- fully reversible within: 4 days
- Remarks on result:
- other: Evaluation stopped after 4 days (96 hour timepoint) as eye had returned to normal.
- Irritation parameter:
- chemosis score
- Remarks:
- conjunctivae
- Basis:
- animal #1
- Remarks:
- Animal number 638, male, 8 weeks, 1.6 kg, treated in right eye
- Time point:
- other: Mean of gradings at 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Some swelling was seen (graded 1/4) 15 minutes after administration. Symptoms had evidently subsided before the 24 hour timepoint.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Remarks:
- Animal number 638, male, 8 weeks, 1.6 kg, treated in right eye
- Time point:
- other: Mean of gradings at 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable, no effects seen.
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- animal #2
- Remarks:
- Animal number 640, male, 8 weeks, 1.9 kg, treated in left eye
- Time point:
- other: Mean of gradings at 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: Evaluation stopped after 2 days (48 hour timepoint) as eye had returned to normal.
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #2
- Remarks:
- Animal number 640, male, 8 weeks, 1.9 kg, treated in left eye
- Time point:
- other: Mean of gradings at 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Some redness was seen (graded 1/3) 15 minutes after administration. Symptoms had evidently subsided before the 24 hour timepoint.
- Irritation parameter:
- chemosis score
- Remarks:
- conjunctivae
- Basis:
- animal #2
- Remarks:
- Animal number 640, male, 8 weeks, 1.9 kg, treated in left eye
- Time point:
- other: Mean of gradings at 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Some swelling was seen (graded 1/4) 15 minutes after administration. Symptoms had evidently subsided before the 24 hour timepoint.
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Remarks:
- Animal number 640, male, 8 weeks, 1.9 kg, treated in left eye
- Time point:
- other: Mean of gradings at 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable, no effects seen.
- Irritant / corrosive response data:
- Corneal damage and conjunctivitis in both eyes was only very slight, with complete repair at 3 and 5 days. Thus, undiluted Jasmatone was considered to be only slightly irritant.
- Other effects:
- No other effects reported.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- An application (10 uL) of undiluted Jasmatone (2-n-hexyl cyclopentanone) was found to be slightly irritating to the eyes of two rabbits, with very slight corneal damage and conjunctivitis observed to be fully reversible within 3 and 5 days.
- Executive summary:
In an in vivo study, conducted prior to the introduction of GLP or the applicable OECD test guideline, undiluted Jasmatone (2 -n-hexyl cyclopentanone, 10 uL) was applied to one eye each of two New Zealand White rabbits. No details on length of application were reported and there is no information in the study report on any rinsing step.
The mean scores (taken across the 24, 48 and 72 hour assessments) for corneal opacity, conjunctival redness, chemosis and iridial damage, were <1 for both animals. Very slight corneal damage and conjunctivis was reported, but was fully reversible within 3 and 5 days. Test substance considered slightly irritating.
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