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Diss Factsheets
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EC number: 209-057-8 | CAS number: 554-00-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: study using an unulual application route but providing useful information
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The detection of carcinogen-induced sperm head abnormalities in mice
- Author:
- Topham JC
- Year:
- 1 980
- Bibliographic source:
- Mutat Res 69, 149-155 (1980)
- Reference Type:
- review article or handbook
- Title:
- BUA report 140: 2,4-Dichloranilin; 2,5-Dichloranilin; 3,4-Dichloranilin.
- Author:
- Beratergremium für umweltrelevante Altstoffe (BUA).
- Year:
- 1 994
- Bibliographic source:
- S Hirzel, Wissenschaftliche Verlagsgesellschaft, Stuttgart ISBN: 3-7776-0618-9
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of 5 male rats received on 5 days i.p. injections of 25, 50, 100, 250 and 500 mg/kg bw 2,4-dichloroaniline dissolved in corn oil. After the 5 week observation period surviving animals were sacrificed and sperm morphology was examined.
- GLP compliance:
- not specified
- Type of method:
- other: ex vivo
Test material
- Reference substance name:
- 2,4-dichloroaniline
- EC Number:
- 209-057-8
- EC Name:
- 2,4-dichloroaniline
- Cas Number:
- 554-00-7
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 2,4-dichloroaniline
- Test material form:
- other: solid
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: F1-Generation from male CBA and female BALB/s mice
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Details on exposure:
- Groups of 5 male rats received on 5 days i.p. injections of 25, 50, 100, 250 and 500 mg/kg bw 2,4-dichloroaniline dissolved in corn oil. After the 5 week observation period surviving animals were sacrificed and sperm morphology was examined.
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- once per day on 5 days
- Frequency of treatment:
- once per day on 5 days
- Duration of test:
- an observation period of 5 weeks followed after the last injection
- No. of animals per sex per dose:
- 5 males
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Groups of 5 male rats received on 5 days i.p. injections of 25, 50, 100, 250 and 500 mg/kg bw 2,4-dichloroaniline dissolved in corn oil. After the 5 week observation period surviving animals were sacrificed and sperm morphology was examined.
- Statistics:
- no data
Results and discussion
Effect levels
open allclose all
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
- Dose descriptor:
- other: NOAEL (sperm head abnormality)
- Effect level:
- ca. 500 mg/kg bw/day (actual dose received)
Observed effects
Applicant's summary and conclusion
- Executive summary:
Groups of 5 male rats received on 5 days i.p. injections of 25, 50, 100, 250 and 500 mg/kg bw 2,4-dichloroaniline dissolved in corn oil. After the 5 week observation period surviving animals were sacrificed and sperm morphology was examined. 2,4 -Dichloroaniline did not induce sperm head abnormality in male mice up to 500 mg/kg bw/day
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