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EC number: 255-925-4 | CAS number: 42739-64-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A screening study for reproductive toxicity (OECD 421, JETOC 1995) performed with the copperphthalocyanine core was used to fill the data gap for reproductive toxicity. It shows absence of effects at the limit dose of 1000 mg/kg bw. The actual argument is however that the substance is not taken up by the body after oral dosing. In support of this, a fourteen day gavage study with doses of 300 and 1000 mg/kg bw was performed with each five male and female rats (BASF 2015). There was no indication of systemic uptake as judged from unchanged plasma and liver copper levels (see also toxicokinetic section). There were no treatment-related clinical signs, no adverse effects on haematology, clinical chemistry, body weights or organ weights. The NOEL for 14-day oral gavage dosing was 1000 mg/kg bw. This study was to performed to support read-across to the core structure copper phthalocyanine (CAS 147-14-8) and to show absence of systemic uptake. Copperphthalocyanine is an inert pigment of extremely low solubility in water (0.0004mg/L) and octanol (0.009mg/L) that is not taken up by experimental animals after oral dosing. Phthalocyanine IM contains additional 1H-isoindole-1,3(2H)-dion subsitutents attached to the ring via a methylene bridge. The substituents add to the conjugated system and contain no charges that do not affect water solubility, they are no ionisable at environmental pH. They increase the diameter and molecular weight which reduces the already non-existent ability for systemic uptake.
Therefore, the reproductive toxicity screening studies with the core structure are suitable for the hazard assessment of CAS 42739 -64 -0
For a detailed read-across justification including a datamatrix, it is referred to the attachment (IUCLID toxicokinetic section).
Short description of key information:
Based on an OECD Guideline 421 and GLP study with CAS number 147-14-8, the NOAEL for reproductive toxicity was considered to be 1000 mg/kg bw/day for all relevant endpoints, which was the highest dose tested.
Effects on developmental toxicity
Description of key information
In an OECD Guideline 421 and GLP study with CAS-nr. 147-14-8 in rats, the NOAEL for development of offspring was at the highest test dose of 1000 mg/kg/day.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Justification for selection of Effect on developmental toxicity: via oral route:
Most reliable study
Justification for classification or non-classification
Based on the results obtained from reproduction/developmental testing, the test substance is not considered to be subject to classification and labelling for toxicity to reproduction/development according to Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (CLP).
Additional information
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