Registration Dossier
Registration Dossier
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EC number: 620-210-1 | CAS number: 13482-22-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-hydroxycyclohexan-1-one
- EC Number:
- 620-210-1
- Cas Number:
- 13482-22-9
- Molecular formula:
- C6H10O2
- IUPAC Name:
- 4-hydroxycyclohexan-1-one
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: contralateral eye untreated
- Observation period (in vivo):
- up to four days after instillation
- Number of animals or in vitro replicates:
- 3 male rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks:
- Cornea
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1, 24, 48, 72 h after instillation
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- overall irritation score
- Remarks:
- Iris
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1, 24, 48, 72 h after instillation
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1, 24, 48, 72 hours
- Score:
- 0 - 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 96 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- chemosis
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- other: 1, 24, 48, 72 hours
- Score:
- 0 - 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 96 hours
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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