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EC number: 630-337-4 | CAS number: 39211-00-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 07 July 1998 (Start of in-life phase) to 30 September 1998 (GLP compliance statement)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reference substance 001
- EC Number:
- 604-086-6
- Cas Number:
- 138577-01-2
- Molecular formula:
- Al.Cs.F
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material: Cesium Fluoro Aluminate Complex
- Purity: 99.5%
- Batch: 604/013
- Physical state: White amorphous powder
- Storage condition of test material: At room temperature in the dark
- Expiration date of the lot/batch: 22 May 2001
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Source: Broekman Institute, Someren, The Netherlands
- Age at study initiation: 7 weeks old
- Weight at study initiation: body weights were less than 1.5 kg
At least prior to dosing, it was ensured that the animals were healthy and that the skin to be treated was intact and free from any abnormality.
- Housing: Animals were individually housed in labeled cages with perforated floors (Scanbur, Denmark) and equipped with an automatic drinking system (ITL, Bergen, The Netherlands).
- Diet: Standard laboratory rabbit diet (LKK-20, pellet diameter 4 mm, Hope Farms, Woerden, The Netherlands) approx. 100 grams per day. In addition, hay (BMI, Helmond, The Netherlands) was provided once a week.
- Water : Free access to tap water diluted with decalcified water.
- Acclimation period: at least 5 days before start of treatment under laboratory conditions.
ENVIRONMENTAL CONDITIONS
- Temperature: controlled at 21°C
- Humidity: controlled at 50 %
- Air changes : approximately 15 room air changes/hour
- Photoperiod : 12-hour light/12-hour dark cycle
Fluctuations from these optimal conditions were noted, but were considered as not to have affected study integrity.
IN-LIFE DATES: From: 7 to 10 July 1998.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
Amount(s) applied : Each animal was treated by dermal application of 0.5 grams of the test substance which was moistened with the vehicle (i.e. water).
VEHICLE
The powdery test substance was moistened with water (Milli-U), immediately before application, to ensure close contact with the animal's skin.
No corrections were made for the purity/composition of the test substance, since the guidelines requires a fixed amount that has to be applied. - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 males.
- Details on study design:
- TEST SITE
Approximately 24 hours before treatment, the dorsal fur was clipped with electric clippers, exposing an area of approximately 150 square centimeters (10x15 cm2). Whenever considered necessary the treated skin areas were reclipped at least 3 hours before the observations, to facilitate the scoring. The test item was applied to the skin of one flank, using a Scotchpak-non-woven patch of 2x3 cm. The patch was mounted on Micropore tape, which was wrapped around the abdomen and secured with Coban elastic bandage.
REMOVAL OF TEST SUBSTANCE
Four hours after the application, the dressing was removed and the skin cleaned of residual test substance using a tissue moistened with tap water and subsequently a dry tissue.
OBSERVATION AND SCORING SYSTEM:
Mortality/Viability: observation twice daily.
Toxicity: observation at least once daily.
Body Weight: day of treatment (prior to application).
Necropsy: No necropsy was performed according to protocol.
Irritation: The skin reactions were assessed at approximately 1, 24, 48 and 72 hours after the removal of the dressings and test substance. The irritation scores and a description of all other (local) effects were recorded. Adjacent areas of the untreated skin of each animal served as controls.
The irritation was assessed according to the following numerical scoring system. At each observation, the highest scores given were recorded:
Erythema and eschar formation:
No erythema .........................................................................................................................................0
Very slight erythema (barely perceptible) ....................................................................................... 1
Well-defined erythema ....................................................................................................................... 2
Moderate to severe erythema.............................................................................................................3
Severe erythema (beet redness) *......................................................................................................4
*. Where signs of necrosis or corrosion (injuries in depth) prevent erythema scoring, the
maximum grade for erythema (= 4) is given.
Oedema formation:
No oedema .............................................................................................................................................0
Very slight oedema (barely perceptible) ............................................................................................1
Slight oedema (edges of area well-defined by definite raising) .....................................................2
Moderate oedema (raised approximately 1 millimeter) ...................................................................3
Severe oedema (raised more than 1 millimeter and extending beyond the area of exposure) 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- Irritation: No skin irritation was caused by 4 hours exposure to cesium fluoro aluminate complex
Corrosion: There was no evidence of a corrosive effect on the skin.
Coloration / Remnants: No staining of the treated skin by the test substance was observed.
Toxicity / Mortality : No symptoms of systemic toxicity were observed in the animals during the test period and no mortality occurred. - Other effects:
- No histopathology was performed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of the study, cesium aluminium fluoride – complex is considered to be not irritating to skin.
- Executive summary:
The primary skin irritation/corrosion of Cesium aluminium fluoride - complex in the rabbit (4-hour semi-occlusive application) was investigated in a study performed according to the OECD Testing Guideline No. 404 and under GLP. Three rabbits were exposed to 0.5 grams of cesium fluoro aluminate complex, applied onto clipped skin for 4 hours using a semi-occlusive dressing. Observations were made 1, 24, 48 and 72 hours after exposure. No skin irritation was observed after 4 hours exposure to cesium fluoro aluminate complex. Based on the results of the study, cesium fluoro aluminate complex is considered to be not irritating to skin.
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